2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. Ro 25-6981 hydrochloride

Ro 25-6981 Hydrochloride 是一种有效的、选择性和活性依赖性的 NR2B 亚基特异性 NMDA 受体 拮抗剂。Ro 25-6981 Hydrochloride 具有抗惊厥和抗帕金森病活性。Ro 25-6981 Hydrochloride 具有研究帕金森病(PD)的潜力。

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Ro 25-6981 hydrochloride Chemical Structure

Ro 25-6981 hydrochloride Chemical Structure

CAS No. : 919289-58-0

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Ro 25-6981 hydrochloride 相关抗体

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AMPA Receptor NMDA Receptor Kainate Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ro 25-6981 hydrochloride is a potent, selective and activity-dependent NR2B subunit specific NMDA receptor antagonist. Ro 25-6981 hydrochloride shows anticonvulsant and anti-parkinsonian activity. Ro 25-6981 hydrochloride has the potential for the research of parkinson's disease (PD)[1][2][3].

体外研究
(In Vitro)

Ro 25-6981 Hydrochloride (0.39-12.5 mg/kg; i.p.) induces contraversive rotations in 6-hydroxydopamine (6-OHDA)-lesioned rats without stimulating locomotion in normal rats[1].
Ro 25-6981 Hydrochloride (1,3 mg/kg; i.p.) exhibits age- and activation-dependent anticonvulsant action at early postnatal development in rats[2].
Ro 25-6981 Hydrochloride (800 µg; intrathecal injection) shows significant analgesic effects on incision pain in rats and effectively attenuated postoperative hyperalgesia induced by remifentanil[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ro 25-6981 hydrochloride 相关抗体:
体内研究
(In Vivo)

Ro 25-6981 Hydrochloride (0.39-12.5 mg/kg; i.p.) induces contraversive rotations in 6-hydroxydopamine (6-OHDA)-lesioned rats without stimulating locomotion in normal rats[1].
Ro 25-6981 Hydrochloride (1,3 mg/kg; i.p.) exhibits age- and activation-dependent anticonvulsant action at early postnatal development in rats[2].
Ro 25-6981 Hydrochloride (800 µg; intrathecal injection) shows significant analgesic effects on incision pain in rats and effectively attenuated postoperative hyperalgesia induced by remifentanil[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-OHDA-lesioned rats[1]
Dosage: 0.39-12.5 mg/kg
Administration: I.p.
Result: Dose-dependently induced contraversive tight nose-to-tail rotations, and induced a weak ipsiversive circling response indicating a mild unspecific stimulatory action of the compound.
Animal Model: Male albino rats of Wistar strain[2]
Dosage: 1, 3 mg/kg
Administration: I.p.
Result: Caused a significant decrease of N1–P2 amplitude at higher stimulation intensities AT 3 mg/kg, and exhibited age- and activation-dependent anticonvulsant action at early postnatal development.
分子量

375.93

Formula

C22H30ClNO2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Ro 25-6981 hydrochloride 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ro 25-6981919289-58-0iGluRIonotropic glutamate receptorsparkinson's diseaseanticonvulsantanti-parkinsonianInhibitorinhibitorinhibit

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