2. GPCR/G Protein Neuronal Signaling
  3. Melanocortin Receptor
  4. RO27-3225 trifluoroacetate

RO27-3225 是黑素皮质素受体 4 (MC4R) 的肽激动剂，具有神经保护和抗炎活性，EC50 值为 1 nM，而 MC1R 为 8 nM。RO27-3225 在失血性休克和复苏大鼠腹腔高压模型中逆转失血性休克，降低脑水肿、血脑屏障 (BBB) 通透性和海马 IL-1β 和 TNF-α 水平。

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RO27-3225 trifluoroacetate Chemical Structure

RO27-3225 trifluoroacetate Chemical Structure

CAS No. : 1373926-49-8

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RO27-3225 trifluoroacetate 相关抗体

Top Publications Citing Use of Products

查看 Melanocortin Receptor 亚型特异性产品:

查看所有亚型
MC1R MC3R MC2R MC4R MC5R

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

RO27-3225 is a peptide agonist of melanocortin receptor 4 (MC4R) with neuroprotective and anti-inflammatory activity with an EC50 value of 1 nM, while 8 nM for MC1R. RO27-3225 Ro 27-3225 reverses hemorrhagic shock, reduces brain edema, blood-brain barrier (BBB) permeability, and hippocampal IL-1β and TNF-α levels in a rat model of intra-abdominal hypertension induced by hemorrhagic shock and resuscitation[1][2].

IC50 & Target

MC4R

1 nM (EC50)

MC1R

8 nM (EC50)

分子量

898.93

Formula

C41H53F3N12O8
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

RO27-3225 trifluoroacetate 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RO27-32251373926-49-8Melanocortin ReceptorMC ReceptorMC4Rneuroprotectiveanti-inflammatoryhemorrhagic shockbrain edemaratInhibitorinhibitorinhibit

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