2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. ROMK-IN-32

ROMK-IN-32 是一种肾外髓质钾通道 (ROMK) 抑制剂，IC50 为 35 nM. ROMK-IN-32 也抑制 hERG ，IC50 为 22 μM。

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ROMK-IN-32 Chemical Structure

ROMK-IN-32 Chemical Structure

CAS No. : 1914944-54-9

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ROMK-IN-32 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ROMK-IN-32 is a renal outer medullary potassium channel (ROMK) inhibitor with an IC50 of 35 nM. ROMK-IN-32 also inhibits hERG with an IC50 of 22 μM[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 IC50
0.035 μM
Compound: 32
Inhibition of human ROMK channel expressed in HEK293 cells after 30 mins by FLIPR based thallium flux assay
Inhibition of human ROMK channel expressed in HEK293 cells after 30 mins by FLIPR based thallium flux assay
[PMID: 28431879]
体外研究
(In Vitro)

ROMK-IN-32 (compound 32) exhibits weak human SERT activity (IC50 10.4 μM; hSERT/hROMK EP=612x)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ROMK-IN-32 相关抗体:
体内研究
(In Vivo)

ROMK-IN-32 demonstrates blood pressure lowering effects in the spontaneously hypertensive rat model[1].
ROMK-IN-32 exhibits moderate oral bioavailability (78%) following oral administration (1 mg/kg) in WH rats[1].
ROMK-IN-32 exhibits terminal elimination half-lives (rat 4.7 and dog 5.8 h) due to high plasma clearance (9.6 and 18.3 mL/min/kg respectively) combined with large volumes of distribution (3.0 and 5.0 L/kg respectively) following intravenous administration (rat 0.5 and dog 1.0 mg/kg)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

452.50

Formula

C24H28N4O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ROMK-IN-32 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ROMK-IN-321914944-54-9Potassium ChannelKcsAhERGROMKHypertensionHeartfailureDiuresisNatriuresisSpirocycleInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-124687
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