2. Metabolic Enzyme/Protease
  3. Angiotensin-converting Enzyme (ACE)
  4. RXPA 380

RXPA 380 是一种 C 端特异性血管紧张素转换酶 (ACE) 抑制剂，Ki 为 3 nM。RXPA 380 抑制人重组 ACE C 域突变体，IC50 为 2.5 nM。

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RXPA 380 Chemical Structure

RXPA 380 Chemical Structure

CAS No. : 564479-79-4

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RXPA 380 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

RXPA 380 is a C-terminal specific angiotensin-converting enzyme (ACE) inhibitor with a Ki of 3 nM. RXPA 380 inhibits C-domain mutants of human recombinant ACE with an IC50 of 2.5 nM[1].

IC50 & Target

Ki: 3 nM (C-terminal ACE), 10 μM (N-terminal ACE)[1]
IC50: 2.5 nM (C-domain mutants of human recombinant ACE), 10 μM (N-domain mutants of human recombinant ACE)[1]
体外研究
(In Vitro)

RXPA 380 shows Ki(app) values of 12 nM and 12 μM for the C- and N-domain of mouse somatic ACE[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

RXPA 380 相关抗体:
体内研究
(In Vivo)

RXPA 380 (0.9-30 mg/kg; i.v.; once) inhibits ACE activity in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL6/J mice[1]
Dosage: 0.9, 3, 10, and 30 mg/kg
Administration: Intravenous infuse for 30 minutes
Result: Induced a dose-dependent decrease of the Ang II/Ang I ratio. Blocked the cleavage of exogenously administered bradykinin.
分子量

617.63

Formula

C33H36N3O7P
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

RXPA 380 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RXPA 380564479-79-4RXPA380RXPA-380Angiotensin-converting Enzyme (ACE)angiotensinbradykininC57BL6/JInhibitorinhibitorinhibit

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RXPA 380
目录号：
HY-18205
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