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  4. S-Methyl-N,N-diethylthiolcarbamate

S-Methyl-N,N-diethylthiolcarbamate  (Synonyms: DETC-Me; DDTC-Me; Diethyldithiocarbamic acid methyl ester)

目录号: HY-151229
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S-Methyl-N,N-diethylthiolcarbamate (DETC-Me; DDTC-Me) 是醛脱氢酶抑制剂双硫仑 (HY-B0240) 的活性代谢物。它由小鼠肝微粒体中双硫仑代谢物二乙基二硫代氨基甲酸甲基化而产生。S-Methyl-N,N-diethylthiolcarbamate (DETC-Me; DDTC-Me)可抑制大鼠肝脏低 Km 醛脱氢酶 (ALDH) (ID50=15.5 mg/kg)。当以 20.6 mg/kg 的剂量给药时，它会降低大鼠平均动脉压 (MAP) 并增加大鼠在乙醇刺激期间的心率。

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S-Methyl-N,N-diethylthiolcarbamate Chemical Structure

S-Methyl-N,N-diethylthiolcarbamate Chemical Structure

CAS No. : 686-07-7

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S-Methyl-N,N-diethylthiolcarbamate 相关抗体

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生物活性

S-Methyl-N,N-diethylthiolcarbamate (DETC-Me; DDTC-Me) is the active metabolite of the aldehyde dehydrogenase inhibitor disulfiram (HY-B0240). It is produced by the methylation of the disulfiram metabolite diethyldithiocarbamate in mouse liver microsomes. S-Methyl-N,N-diethylthiolcarbamate (DETC-Me; DDTC-Me) inhibits rat liver low Km aldehyde dehydrogenase (ALDH) (ID50=15.5 mg/kg). When administered at a dose of 20.6 mg/kg, it decreases mean arterial pressure (MAP) and increases heart rate in rats during ethanol stimulation.

分子量

163.30

Formula

C6H13NS2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

S-Methyl-N,N-diethylthiolcarbamate 相关分类

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Keywords:

S-Methyl-N,N-diethylthiolcarbamate686-07-7DETC-Me DDTC-Me Diethyldithiocarbamic acid methyl esterOthersInhibitorinhibitorinhibit

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