(S)-Monastrol (Synonyms: (+)-Monastrol)

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(S)-Monastrol ((+)-Monastrol) 是一种有丝分裂运动蛋白 Eg5 的变构抑制剂，对多种癌细胞系具有抗增殖作用。(S)-Monastrol 抑制哺乳动物单极纺锤体有丝分裂中的细胞。

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(S)-Monastrol Chemical Structure

CAS No. : 254753-54-3

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(S)-Monastrol 相关产品

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Kinesin-5/Eg5/KSP Kinesin-6 Kinesin-7/CENP-E Kinesin-12 Kinesin-14

生物活性
纯度 & 产品资料
参考文献

生物活性

(S)-Monastrol ((+)-Monastrol) is an allosteric inhibitor of the mitotic kinesin Eg5 that exhibits an antiproliferative effect against several cancer cell lines. (S)-Monastrol arrests mammalian cells in mitosis with monopolar spindles^[1]^[2].

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
A-431	IC₅₀	53 μg/mL Compound: Monastrol	Cytotoxicity against human A431 cells after 48 hrs by MTT assay Cytotoxicity against human A431 cells after 48 hrs by MTT assay	[PMID: 21620531]
A549	IC₅₀	> 10 μM Compound: Monastrol	Cytotoxicity against human A549 cells after 48 hrs by SRB assay Cytotoxicity against human A549 cells after 48 hrs by SRB assay	[PMID: 21856161]
A549	IC₅₀	> 100 μM Compound: 1	Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay	[PMID: 31673316]
A549	IC₅₀	118 μg/mL Compound: Monastrol	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 21620531]
AGS	IC₅₀	> 10 μM Compound: Monastrol	Cytotoxicity against human AGS cells after 48 hrs by SRB assay Cytotoxicity against human AGS cells after 48 hrs by SRB assay	[PMID: 21856161]
BXPC-3	EC₅₀	> 100 nM Compound: rac-monastrol	Antiproliferative activity against human BxPC3 cells after 72 hrs by Alamar blue assay Antiproliferative activity against human BxPC3 cells after 72 hrs by Alamar blue assay	[PMID: 20597485]
C6	IC₅₀	> 200 μM Compound: 1	Antiproliferative activity against rat C6 cells after 24 hrs by MTS assay Antiproliferative activity against rat C6 cells after 24 hrs by MTS assay	[PMID: 30108989]
C6	IC₅₀	87.83 μM Compound: Manastrol	Cytotoxicity against rat C6 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against rat C6 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 30151081]
COLO 205	IC₅₀	164 μg/mL Compound: Monastrol	Cytotoxicity against human COLO205 cells after 48 hrs by MTT assay Cytotoxicity against human COLO205 cells after 48 hrs by MTT assay	[PMID: 21620531]
HCT-116	IC₅₀	> 50 μM Compound: Monastrol	Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay	[PMID: 20934346]
HCT-116	EC₅₀	1.2 μM Compound: monastrol	Effect on cell cycle progression in human HCT116 cells assessed as mitotic arrest measured by doubling DNA content by fluorescence microscopy Effect on cell cycle progression in human HCT116 cells assessed as mitotic arrest measured by doubling DNA content by fluorescence microscopy	[PMID: 18793847]
HCT-116	EC₅₀	1.5 μM Compound: monastrol	Effect on cell cycle progression in human HCT116 cells assessed as increase in phospho-histone H3 by fluorescence microscopy Effect on cell cycle progression in human HCT116 cells assessed as increase in phospho-histone H3 by fluorescence microscopy	[PMID: 18793847]
HCT-116	EC₅₀	24155 nM Compound: rac-monastrol	Antiproliferative activity against human HCT116 cells after 72 hrs by Alamar blue assay Antiproliferative activity against human HCT116 cells after 72 hrs by Alamar blue assay	[PMID: 20597485]
HCT-116	IC₅₀	9 μM Compound: 1	Antiproliferative activity against human HCT116 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human HCT116 cells incubated for 72 hrs by MTT assay	[PMID: 31673316]
HeLa	IC₅₀	176.9 μM Compound: Monastrol	Cytotoxicity against human HeLa cells assessed as decrease in cell viability after 72 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as decrease in cell viability after 72 hrs by MTT assay	[PMID: 29908443]
HeLa	IC₅₀	51.3 μM Compound: 1, monastrol	Induction of monoastral spindles in HeLa cells after 7 hrs Induction of monoastral spindles in HeLa cells after 7 hrs	[PMID: 17587586]
HeLa	IC₅₀	6.1 μM Compound: 1, monastrol	Inhibition of Eg5 ATPase activity expressed in HeLa cells after 12 hrs Inhibition of Eg5 ATPase activity expressed in HeLa cells after 12 hrs	[PMID: 17587586]
HL-60(TB)	IC₅₀	0.147 μM Compound: Monastrol	Growth inhibition of human HL-60(TB) cells incubated for 24 hrs by MTT assay Growth inhibition of human HL-60(TB) cells incubated for 24 hrs by MTT assay	[PMID: 28667871]
K562	EC₅₀	> 100 nM Compound: rac-monastrol	Antiproliferative activity against human K562 cells after 72 hrs by Alamar blue assay Antiproliferative activity against human K562 cells after 72 hrs by Alamar blue assay	[PMID: 20597485]
KB 3-1	EC₅₀	56494 nM Compound: rac-monastrol	Antiproliferative activity against human KB3-1 cells after 72 hrs by Alamar blue assay in presence of zosuquidar Antiproliferative activity against human KB3-1 cells after 72 hrs by Alamar blue assay in presence of zosuquidar	[PMID: 20597485]
KB 3-1	EC₅₀	85114 nM Compound: rac-monastrol	Antiproliferative activity against human KB3-1 cells after 72 hrs by Alamar blue assay Antiproliferative activity against human KB3-1 cells after 72 hrs by Alamar blue assay	[PMID: 20597485]
KB-V1	EC₅₀	45394 nM Compound: rac-monastrol	Antiproliferative activity against human KBV1 cells overexpressing MDR1 after 72 hrs by Alamar blue assay in presence of zosuquidar Antiproliferative activity against human KBV1 cells overexpressing MDR1 after 72 hrs by Alamar blue assay in presence of zosuquidar	[PMID: 20597485]
KB-V1	EC₅₀	99083 nM Compound: rac-monastrol	Antiproliferative activity against human KBV1 cells overexpressing MDR1 after 72 hrs by Alamar blue assay Antiproliferative activity against human KBV1 cells overexpressing MDR1 after 72 hrs by Alamar blue assay	[PMID: 20597485]
MCF7	IC₅₀	45 μg/mL Compound: Monastrol	Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 21620531]
MCF7	IC₅₀	59.1 μM Compound: Monastrol	Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 72 hrs by MTT assay	[PMID: 29908443]
MCF7	IC₅₀	73 μM Compound: 1	Antiproliferative activity against human MCF7 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells incubated for 72 hrs by MTT assay	[PMID: 31673316]
MM1.S	IC₅₀	8.7 μM Compound: 1	Antiproliferative activity against human MM1S cells incubated for 72 hrs by MTT assay Antiproliferative activity against human MM1S cells incubated for 72 hrs by MTT assay	[PMID: 31673316]
MOLT-4	IC₅₀	0.215 μM Compound: Monastrol	Growth inhibition of human MOLT4 cells incubated for 24 hrs by MTT assay Growth inhibition of human MOLT4 cells incubated for 24 hrs by MTT assay	[PMID: 28667871]
NCI-H1299	EC₅₀	> 100 nM Compound: rac-monastrol	Antiproliferative activity against human NCI-H1299 cells after 72 hrs by Alamar blue assay Antiproliferative activity against human NCI-H1299 cells after 72 hrs by Alamar blue assay	[PMID: 20597485]
U138-MG	IC₅₀	> 200 μM Compound: 1	Antiproliferative activity against human U138MG cells after 24 hrs by MTS assay Antiproliferative activity against human U138MG cells after 24 hrs by MTS assay	[PMID: 30108989]

分子量

292.35

Formula

C₁₄H₁₆N₂O₃S

CAS 号

254753-54-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料

产品使用指南 (1538 KB)

参考文献

[1]. Marques LA, et al. Antiproliferative activity of monastrol in human adenocarcinoma (MCF-7) and non-tumor (HB4a) breast cells. Naunyn Schmiedebergs Arch Pharmacol. 2016 Dec;389(12):1279-1288. [Content Brief]

[2]. Mayer TU, et al. Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen. Science. 1999 Oct 29;286(5441):971-4. [Content Brief]

(S)-Monastrol 相关分类

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量		浓度		体积		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)	×	体积 _(start)	=	浓度 _(final)	×	体积 _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S)-Monastrol254753-54-3(+)-MonastrolKinesinMCF-7HB4aadenocarcinomaInhibitorinhibitorinhibit

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上海工商

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沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

(S)-Monastrol (Synonyms: (+)-Monastrol)

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(S)-Monastrol 相关产品

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(S)-Monastrol (Synonyms: (+)-Monastrol)

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(S)-Monastrol 相关抗体

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生物活性

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