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  4. S2/IAPinh

S2/IAPinh 由凋亡蛋白抑制剂 (IAPinh) 的抑制剂和 sigma 2 SW43 的配体组成的偶联物。S2/IAPinh 通过降解细胞凋亡蛋白抑制剂 (clAP-1) 表现出抗增殖和凋亡诱导活性。

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S2/IAPinh Chemical Structure

S2/IAPinh Chemical Structure

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S2/IAPinh 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

S2/IAPinh is a conjugate, which consist of an inhibitor for the apoptosis protein inhibitor (IAPinh) and a ligand for sigma 2 SW43. S2/IAPinh exhibits an anti-proliferative and apoptotic-inducing effect through degradation of the cellular inhibitor for apoptosis protein (clAP-1)[1].

体外研究
(In Vitro)

S2/IAPinh (0-100 μM) 在人胰腺癌细胞系 AsPC-1、HPAC 和 MiaPaCa-2，小鼠胰腺癌细胞系 KP2 和人卵巢癌细胞系 OVCAR3/8 中表现出细胞毒性，IC50 为 4.6 至 12.8 μM，并通过激活 caspase 3 和 caspase 8 诱导 HPAC 和 OVCAR8 中的细胞凋亡 (apoptosis)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

S2/IAPinh 相关抗体:

Cell Viability Assay[1]

Cell Line: AsPC-1, HPAC, MiaPaCa-2, KP2, OVCAR3, OVCAR8
Concentration: 0-100 μM
Incubation Time: 24 h
Result: Inhibits cell proliferations.

Apoptosis Analysis[1]

Cell Line: HPAC and OVCAR8
Concentration: 6 μM
Incubation Time: 6 h
Result: Induced DNA break.
体内研究
(In Vivo)
分子量

1002.16

Formula

C52H75Cl2FN6O6S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

S2/IAPinh 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

S2/IAPinhOtherspancreatic cancerovarian cancerAsPC-1HPACMiaPaCa-2KP2OVCAR3OVCAR8C57BL/6 mouseInhibitorinhibitorinhibit

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目录号：
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