2. Anti-infection
  3. SARS-CoV
  4. SARS-CoV-2-IN-10

SARS-CoV-2-IN-10 是一种有效且无毒的 SARS-CoV-2 3CL 蛋白酶 (3CLpro) 抑制剂，IC50 和 EC50 分别为 0.13 和 1.03 nM。SARS-CoV-2 3C 样蛋白酶 (3CLpro) 是病毒复制所必需的酶，是干预的一个有吸引力的目标。SARS-CoV-2-IN-11 可能导致有效的 SARS-CoV-2 特异性抗病毒活性分子的出现。

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SARS-CoV-2-IN-10 Chemical Structure

SARS-CoV-2-IN-10 Chemical Structure

CAS No. : 2722634-95-7

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SARS-CoV-2-IN-10 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SARS-CoV-2-IN-10 is a potent and nontoxic inhibitor of SARS-CoV-2 3CL protease (3CLpro) with an IC50 and EC50 of 0.13 and 1.03 nM, respectively. SARS-CoV-2 3C-like protease (3CLpro), an enzyme essential for viral replication, is an attractive target for intervention. SARS-CoV-2-IN-11 may lead to the emergence of effective SARS-CoV-2-specific antivirals[1].

IC50 & Target

SARS-CoV-2 3C-like protease[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK-293T CC50
> 100 μM
Compound: 15b
Cytotoxicity against HEK293T cells assessed as reduction in cell viability measured after 72 hrs by CytoTox 96 nonradioactive cytotoxicity assay
Cytotoxicity against HEK293T cells assessed as reduction in cell viability measured after 72 hrs by CytoTox 96 nonradioactive cytotoxicity assay
[PMID: 34865476]
分子量

521.60

Formula

C27H37F2N3O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SARS-CoV-2-IN-10 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SARS-CoV-2-IN-102722634-95-7SARS-CoVSARS coronavirusnontoxicSARS-CoV-2 3CL protease3CLproantiviralInhibitorinhibitorinhibit

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