2. Anti-infection
  3. SARS-CoV
  4. SARS-CoV-2-IN-27

SARS-CoV-2-IN-27 是一种双臂二磷酸 C6 烷基酯和具有扩展长度的分子镊子。SARS-CoV-2-IN-27 具有抗病毒活性，抑制 SARS-CoV-2 活力和病毒尖刺伪粒子转导的 IC50 分别为 1.0 μM 和 1.7 μM。SARS-CoV-2-IN-27 引起脂质体膜破坏，EC50 为 6.5 μM。

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SARS-CoV-2-IN-27 Chemical Structure

SARS-CoV-2-IN-27 Chemical Structure

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Customer Review

Other Forms of SARS-CoV-2-IN-27:

SARS-CoV-2-IN-27 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SARS-CoV-2-IN-27 is a two-armed diphosphate ester with C6 alkyl and molecular tweezers with extended length. SARS-CoV-2-IN-27 exhibits antiviral activity with IC50s of 1.0 μM and 1.7 μM against SARS-CoV-2 activity and the spike pseudoparticle transduction, respectively. SARS-CoV-2-IN-27 induces liposomal membrane disruption with an EC50 value of 6.5 μM[1].

IC50 & Target

IC50: 6.5 μM (viral liposome, SARS-CoV-2)[1]
体外研究
(In Vitro)

SARS-CoV-2-IN-27 (CP019) inhibits SARS-CoV-2 (IC50=1.7 μM) with few cytotoxicity (Caco2 cells, CC50=208 μM)[1].
SARS-CoV-2-IN-27 (0-15 μM; 2 h) inactivate SARS-CoV-2, shows inhibition against infection with an IC50 value of 1.0 μM[1].
SARS-CoV-2-IN-27 suppresses varies enveloped viruses activity with IC50s of 7.4 μM (respiratory syncytial virus, RSV), 112.6 μM (influenza A virus, IAV), 4.6 μM (measles virus, MeV), 1.8 μM (herpes simplex viruses, HSV-1), respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SARS-CoV-2-IN-27 相关抗体:

Cell Viability Assay[1]

Cell Line: Caco2 cells exposed with SARS-CoV-2 (2 h, 37 ℃)
Concentration: 0, 0.23, 0.93, 3.75, 15 μM
Incubation Time: 2 hours; determined infection rates on day 2
Result: Inhibited SARS-CoV-2 infection activity to Caco2 cells.
体内研究
(In Vivo)

SARS-CoV-2-IN-27 (CP019) (150 μM, 50 μL; intranasal route; for 2-5 d) shows antiviral activity in vivo against respiratory syncytial virus (RSV) and SARS-CoV-2 in BALB/cJ mice or K18-hACE2 mice, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Respiratory syncytial virus (RSV) infection of BALB/cJ mice and SARS-CoV-2 infection of K18-hACE2 mice[1]
Dosage: 150 μM, 50 μL
Administration: Intranasal route; single dose; sacrificed BALB/cJ mice on day 5; treated K18-hACE2 mice once again after 7 h and sacrificed mice on day 2
Result: Reduced viral load in the lungs of SARS-CoV-2-infected mice.
Completely abolished SARS-CoV-2 infection of all tested mice without changing body weight of mice.
分子量

894.97

Formula

C54H56O8P2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SARS-CoV-2-IN-27 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SARS-CoV-2-IN-27SARS-CoVSARS coronavirusbroad-spectrum antiviralsSARS-CoV-2RSVmolecular tweezersrespiratory virusesliposometwo-armed diphosphate esterinfluenza A virusIAVmeasles virusMeVherpes simplex virusesHSV-1C6 alkyl derivativeInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-151271
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