2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. SB-236057

SB-236057 是一种 5-HT1B 受体的反向激动剂，在啮齿动物和兔子中表现出强烈的骨骼致畸性。SB-236057 通过对 Notch 信号通路的干扰并与 r-esp1 相互作用来影响胚胎发育过程中的基因表达。SB-236057 在早期器官发生期大鼠胚胎中诱导体细胞模式和尾端延伸缺陷。

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SB-236057 Chemical Structure

SB-236057 Chemical Structure

CAS No. : 180083-49-2

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SB-236057 相关抗体

Top Publications Citing Use of Products

查看 5-HT Receptor 亚型特异性产品:

查看所有亚型
5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SB-236057 is an inverse agonist of the 5-HT1B receptor that exhibits strong skeletal teratogenicity in rodents and rabbits. SB-236057 affects gene expression during embryonic development through interference with the Notch signaling pathway and interaction with r-esp1. SB-236057 induces somatic patterning and tail extension defects in rat embryos during early organogenesis[1].

分子量

534.65

Formula

C33H34N4O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SB-236057 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SB-236057180083-49-2SB236057SB 2360575-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorInverse agonistsskeletal teratogensembryonic developmentsomatic patterningtail extension defectsInhibitorinhibitorinhibit

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产品名称：
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目录号：
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