2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. SB26019

SB26019 是一种有效的抗神经炎症剂。SB26019 通过诱导单体 α-微管蛋白 (α-tubulin) 形成来调节 NF-κB 激活。SB26019 诱导的 α-微管蛋白单体抑制 p65 易位。

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SB26019 Chemical Structure

SB26019 Chemical Structure

CAS No. : 1233078-90-4

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SB26019 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SB26019 is a potent anti-neuroinflammatory agent. SB26019 regulates NF-κB activation by inducing monomeric α-tubulin formation. SB26019-induced α-tubulin monomer inhibits p65 translocation[1].

体外研究
(In Vitro)

SB26019（10 μM；持续 6 小时）抑制炎症标记基因的产生，例如 Ccl2、Cxcl10、Il-1β、Il-6、Nos2 和 Tnf[1]。
SB26019 (1.25-10 μM; 1-12 h) 以时间和剂量依赖的方式诱导 IκB 降解[1]。
SB26019（IC50 为 1.13 μM）与抗炎调节剂秋水仙碱（IC50 为 4.20 μM）相比，产生更多的 α-微管蛋白单体和更少的微管蛋白聚合物[1].
SB26019 (10 μM) 诱导的 α-微管蛋白单体抑制 J774A.1 和 RAW264.7 小鼠巨噬细胞中的 p65 易位[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SB26019 相关抗体:

RT-PCR[1]

Cell Line: BV-2 murine microglial cells
Concentration: 10 μM
Incubation Time: 6 h
Result: Suppressed the production of inflammatory marker genes.

Western Blot Analysis[1]

Cell Line: J774A.1 cells
Concentration: 1.25 μM, 2.5 μM, 5 μM, 10 μM
Incubation Time: 1 h, 3 h, 6 h, 12 h
Result: Dose- and time-dependent IκB degradation without affecting the total amount of p65 in J774A.1 cells.
体内研究
(In Vivo)

SB26019（2-5mg/kg；i.p；每天；持续 4 天）改善体内神经炎症[1]。 Pharmacokinetic (PK) analysis of SB26019[1].

Parameters I.P.,5 mg/kg
Tmax (h) 0.17 ± 0.00
Cmax (μg/mL) 1.20 ± 0.26
T1/2 (h) 3.57 ± 0.62
AUCt (μg h/mL) 1.77 ± 0.30
AUC∞ (μg h/mL) 1.79 ± 0.31
CL (L/h/kg) NA
Vss (L/kg) NA
Ft (%) NA

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 10-week-old female C57BL/6 mice (20-25 g)[1]
Dosage: 2 mg/kg, 5 mg/kg
Administration: i.p; daily; for 4 days
Result: Suppressed microglial activation by downregulating lba-1 and proinflammatory cytokines.
分子量

372.41

Formula

C24H20O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SB26019 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SB260191233078-90-4SB 26019SB-26019Microtubule/Tubulinanti-neuroinflammatory activityp65NF-κBα-tubulinlba-1Inhibitorinhibitorinhibit

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