2. Cell Cycle/DNA Damage Apoptosis Epigenetics
  3. PARP Apoptosis
  4. Schisandronic acid

Schisandronic acid  (Synonyms: Ganwuweizic acid)

目录号: HY-118129
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摩尔计算器

Schisandronic acid 是一种可从红花五味子中提取得到三萜类抗氧化剂和抗癌剂，对人类乳腺癌细胞（尤其是 MCF-7）具有强效的细胞毒性。Schisandronic acid 以时间依赖性方式诱导细胞凋亡并降低细胞活力 (MCF-7, IC50=8.06 μM)。Schisandronic acid 可上调活性 caspase-3 表达并裂解 PARP，减少活性氧的产生和表现出抗氧化作用。

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Schisandronic acid Chemical Structure

Schisandronic acid Chemical Structure

CAS No. : 55511-14-3

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Schisandronic acid 相关抗体

Top Publications Citing Use of Products

查看 PARP 亚型特异性产品:

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PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Schisandronic acid is a triterpenoid antioxidant and anticancer agent extracted from Schisandra chinensis, which has potent cytotoxicity against human breast cancer cells, especially MCF-7. Schisandronic acid induces apoptosis and reduces cell viability in a time-dependent manner (MCF-7, IC50=8.06 μM). Schisandronic acid can upregulate active caspase-3 expression and cleave PARP, reduce the generation of reactive oxygen species and exhibit antioxidant effects[1].

分子量

454.68

Formula

C30H46O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Schisandronic acid 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

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Keywords:

Schisandronic acid55511-14-3Ganwuweizic acidPARPApoptosispoly ADP ribose polymerase Inhibitorinhibitorinhibit

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