1. 多肽产品
  2. 多肽及其衍生物
  3. 抑制剂与底物肽
  4. Scospondistatin

Scospondistatin 是一种抗血管生成肽,可以在体外抑制人脐静脉内皮细胞的增殖和迁移。

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Custom Peptide Synthesis

Scospondistatin Chemical Structure

Scospondistatin Chemical Structure

CAS No. : 929555-18-0

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

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Customer Review

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Scospondistatin is an anti-angiogenic peptide that can inhibit proliferation and migration of human umbilical vein endothelial cells in vitro[1].

体外研究
(In Vitro)

Scospondistatin (0.01-40 μg/mL; 3 d) 以剂量依赖的方式抑制人脐静脉内皮细胞 (HUVECs) 增殖[1]
Scospondistatin (30 μg/mL; 20 h) 在 VEGF 存在时,显著抑制 HUVECs 的迁移[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: HUVECs
Concentration: 0.01, 0.1, 1, 10, 20, 30 and 40 μg/mL
Incubation Time: 3 days
Result: Showed a monotonic dose response, with the anti-proliferative activity increasing with increasing the peptide concentration.

Cell Migration Assay [1]

Cell Line: HUVECs
Concentration: 1, 10 and 30 μg/mL
Incubation Time: 20 h
Result: Significantly inhibited the migration of HUVECs in the presence of VEGF at 30 μg/mL.
分子量

2023.17

Formula

C81H127N27O30S2

CAS 号
Sequence Shortening

GPWEDCSVSCGGGEQLRSR

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
细胞实验: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Scospondistatin
目录号:
HY-P3995
需求量: