2. Metabolic Enzyme/Protease
  3. MMP
  4. SD-7300

SD-7300  (Synonyms: SC-81490; PF-02881307)

目录号: HY-164525
产品使用指南

摩尔计算器

SD-7300 (SC-81490) 是一种具有口服活性的 MMP-2、MMP-9 和 MMP-13 的抑制剂，Ki 值分别为 0.03、0.01 和 0.03 nM。SD-7300 能够减少肿瘤细胞对细胞外基质的降解，从而抑制肿瘤细胞的侵袭和转移。此外，SD-7300 也是一种剂量依赖性的小鼠角膜血管生成抑制剂，以及白细胞介素-1 诱导的牛软骨降解抑制剂。SD-7300 可用于乳腺癌的研究。

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SD-7300 Chemical Structure

SD-7300 Chemical Structure

CAS No. : 748120-89-0

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SD-7300 相关抗体

Top Publications Citing Use of Products

查看 MMP 亚型特异性产品:

查看所有亚型
MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SD-7300 (SC-81490) is an orally active inhibitor of MMP-2, MMP-9, and MMP-13 with Ki values ??of 0.03, 0.01, and 0.03 nM, respectively. SD-7300 can reduce the degradation of extracellular matrix by tumor cells, thereby inhibiting the invasion and metastasis of tumor cells. In addition, SD-7300 is also a dose-dependent inhibitor of mouse corneal angiogenesis and an inhibitor of interleukin-1-induced bovine cartilage degradation. SD-7300 can be used in breast cancer research[1].

IC50 & Target[1]

MMP-2

0.03 nM (Ki)

MMP-9

0.01 nM (Ki)

MMP13

0.03 nM (Ki)

分子量

525.54

Formula

C21H30F3N3O7S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SD-7300 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SD-7300748120-89-0SC-81490 PF-02881307SD7300SD 7300SC81490SC 81490PF02881307PF 02881307PF-02881307MMPMatrix metalloproteinasesinhibitorangiogenesistumor invasionextracellular matrixbreast cancerInhibitorinhibit

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