Natural products analogue

By Targets:	Apoptosis (1) Cytochrome P450 (1) Monoamine Oxidase (1) Proteasome (1)
By Research Areas:	Cancer (2) Neurological Disease (1)

Cat. No.	Product Name	Target	Research Area	Chemical Structure

HY-146958

MAO-B-IN-8 1 篇文献验证	Monoamine Oxidase	Neurological Disease
MAO-B-IN-8 是一种有效的可逆的 MAO-B 抑制剂和一种神经炎症介质小胶质细胞生成抑制剂。MAO-B-IN-8 可用于神经退行性疾病研究。

HY-N8609

Uralsaponin C	Others	Others
Uralsaponin C 是齐墩烷型三萜皂苷的类似物。Uralsaponin C 可从甘草的根中分离得到。

HY-108553

Dihydroeponemycin	Proteasome Apoptosis	Cancer
Dihydroeponemycin, 是抗肿瘤和抗血管生成天然产物埃普霉素的类似物，选择性靶向 20S 蛋白酶体 (20S proteasome)。Dihydroeponemycin 共价修饰催化蛋白酶体亚单位的子集，优先与IFN-γ 诱导亚单位 LMP2 和 LMP7 结合Dihydroeponemycin 介导的蛋白酶体抑制诱导纺锤样细胞形态变化和细胞凋亡 (apoptosis)。

HY-N4205R

Tetrahydropiperine (Standard)	Cytochrome P450	Cancer
四氢胡椒碱 (Standard) Tetrahydropiperine (Standard)是 Tetrahydropiperine 的分析标准品。本产品用于研究及分析应用。Tetrahydropiperine 是胡椒碱的环己基类似物，是来自 Piper longum 的第一种天然芳基戊酰胺。 Tetrahydropiperine (compound 14) 抑制细胞色素 P450 (CYP) 同工型 CYP1A1/芳基烃羟化酶 (AHH；IC₅₀=23 µM)。

Cat. No.	Product Name

HY-L0120V

Asinex BioDesign Library	170,269 compounds
“BioDesign” approach incorporates key structural features of known pharmacologically relevant natural products (e.g. alkaloids and other secondary metabolites) into synthetically feasible medicinal chemistry scaffolds. In order to identify the privileged pharmacophores, ring systems and linkers, we have carried out statistical analysis of structural features of natural products, marketed drugs, and drug candidates. Saturated, fused ring, spiro, and bridged systems with a tendency towards multiple chiral centers are highly privileged among natural products and marketed drugs yet these structures are very poorly represented in commercial libraries. This library addressed this market need by incorporating these privileged elements into the design of novel synthetic molecules with high molecular framework diversity, multiple stereogenic centers (≥2), and degree of saturation (Fsp3 > 0.5).

Asinex BioDesign Library

170,269 compounds

“BioDesign” approach incorporates key structural features of known pharmacologically relevant natural products (e.g. alkaloids and other secondary metabolites) into synthetically feasible medicinal chemistry scaffolds. In order to identify the privileged pharmacophores, ring systems and linkers, we have carried out statistical analysis of structural features of natural products, marketed drugs, and drug candidates.

Saturated, fused ring, spiro, and bridged systems with a tendency towards multiple chiral centers are highly privileged among natural products and marketed drugs yet these structures are very poorly represented in commercial libraries. This library addressed this market need by incorporating these privileged elements into the design of novel synthetic molecules with high molecular framework diversity, multiple stereogenic centers (≥2), and degree of saturation (Fsp3 > 0.5).

HY-L0082V

Nucleoside Mimetics Library	290 compounds
A library of 290 nucleoside mimetics.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N8609

Uralsaponin C	Triterpenes Structural Classification Leguminosae Ketones, Aldehydes, Acids Terpenoids Source classification Plants Glycyrrhiza uralensis Fisch.	Others
Uralsaponin C 是齐墩烷型三萜皂苷的类似物。Uralsaponin C 可从甘草的根中分离得到。

HY-N4205R

Tetrahydropiperine (Standard)	Alkaloids Piperidine Alkaloids Structural Classification Source classification Piperaceae Plants Piper nigrum Linn.	Cytochrome P450
四氢胡椒碱 (Standard) Tetrahydropiperine (Standard)是 Tetrahydropiperine 的分析标准品。本产品用于研究及分析应用。Tetrahydropiperine 是胡椒碱的环己基类似物，是来自 Piper longum 的第一种天然芳基戊酰胺。 Tetrahydropiperine (compound 14) 抑制细胞色素 P450 (CYP) 同工型 CYP1A1/芳基烃羟化酶 (AHH；IC₅₀=23 µM)。

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