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15

抑制剂 & 激动剂

6

化合物筛选库

1

多肽产品

1

天然产物

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Cat. No. Product Name
  • HY-L905
    类天然产物库
    		5,000 compounds

    历史上，天然产物在药物发现中起着关键的作用，特别是在癌症和传染病的治疗领域，其他的治疗领域也包括心血管疾病（如他汀类药物），多发性硬化症（如腺苷酯）等。过去的几十年里，FDA 批准的药物中大约有 40% 是天然产物，其衍生物或与天然产物相关的类似物。

    MCE 5K Natural Product-like Compound Library 由 5,000 个类天然产物化合物组成，库中每个分子含有天然产物关键骨架（42个）或者和天然产物的谷本相似系数 >0.6，且 Natural-likeness scoring >-2。该化合物库同时具备类药性和新颖性，库中化合物可重复供应，是新药研发的有力工具，可以广泛地应用于高通量筛选（HTS）和高内涵筛选（HCS）。
  • HY-L0107V
    Life Chemicals 天然产物类似物库
    		13,236 compounds
    Natural products are small molecules produced naturally by any organism including primary and secondary metabolites. Nowadays, new drugs based on Natural products are successfully applied to treat tumors, viral and bacterial diseases, and nervous disorders. In response to the current drug discovery demand, we created this natural product-like compound library with 13,236 in-stock synthetic compounds similar to natural ones. The library was designed by 2D fingerprint similarity filtering, chemical descriptor-based and natural-likeness scoring selection. These compounds are useful tools for high throughput screening (HTS) and high content screening (HCS) programs.
  • HY-L0122V
    Asinex CNS Macrocycles Library
    		1,122 compounds
    Several CNS multi-parameter scoring approaches have been reported: CNS-MPO, CNS-MPO V.2, CNS-TEMPO, which suggesting an algorithm to predict CNS-ike properties of new chemical entities. We have applied these scoring algorithms to select macrocycles satisfying multiple cut-offs and structural desirability criteria. The resulting set consists of 1,122 macrocyclic compounds with CNS-MPO > 4, CNS-MPO.v2 > 4, and CNS-TEMPO < 4 for CNS-related drug discovery and research.
  • HY-L0065V
    CNS Library
    		47,360 compounds
    A unique collection of 47,360 novel small molecules with high CNS MPO (Central Nervous System Multiparameter Optimization) scores. The CNS-active molecules which are able to penetrate blood-brain barrier (BBB) were low polar surface area, low degree of possible hydrogen bond formation and low ClogP values.
  • HY-L0121V
    MCE 10K Natural Product-like Compound Library
    		10,000 compounds

    Natural products are an attractive source with varied structures that exhibit potent biological activities, and desirable pharmacological profiles. The core scaffold of a natural product can also provide a biologically validated framework upon which to display diverse functional groups. Inspired by bioactive natural products, natural product-like compounds, occupying the same chemical space, are ideally suited to explore and to facilitate understanding of biological pathways.

    MCE 10K Natural Product-like Compound Library consists of 10,000 natural product-like compounds. Each compound has scaffold of natural products or Tanimoto coefficient >0.6 with natural products. The natural-likeness scoring of these compounds is >-2. What’s more, compounds in the library are drug-like and readily available for re-supply, making it a powerful tool for new drug research and development. It can be widely applied in high-throughput screening (HTS) and high-content screening (HCS).
  • HY-L0079V
    Glycomimetic Library
    		2,470 compounds
    A specially synthesized set of 2 compounds able to mimic glycosides and their interaction with proteins. The main emphasis of library design was made on drug-like compounds enriched with H-bond donors (possess at least two H-bond donors) and bearing nature-like Fsp3–rich scaffolds with diverse spatial orientation of H-bond donors and different 3D-shapes.

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