2. 一站式药筛
  3. 化合物库
  4. 类天然产物库
类天然产物库 - Natural Product-like Compound Library

Cat. No.: HY-L905

历史上，天然产物在药物发现中起着关键的作用，特别是在癌症和传染病的治疗领域，其他的治疗领域也包括心血管疾病（如他汀类药物），多发性硬化症（如腺苷酯）等。过去的几十年里，FDA 批准的药物中大约有 40% 是天然产物，其衍生物或与天然产物相关的类似物。

MCE 5K Natural Product-like Compound Library 由 5,000 个类天然产物化合物组成，库中每个分子含有天然产物关键骨架（42个）或者和天然产物的谷本相似系数 >0.6，且 Natural-likeness scoring >-2。该化合物库同时具备类药性和新颖性，库中化合物可重复供应，是新药研发的有力工具，可以广泛地应用于高通量筛选（HTS）和高内涵筛选（HCS）。

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
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Compound Screening Libraries

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描述&特点

Biological Activity

•    A unique collection of natural product-like compound library.

•    Each molecule contains scaffold of natural products or has a Tanimoto similarity coefficient greater than 0.6 with 40K natural products, and natural-likeness scoring is more than -2.

•    Compatible with “Lipinski” s Rule of Five”, with multiple characteristics such as calculated good permeability (-3.2

•    Passed all associated MedChem filters, particularly pan assay interference compound (PAINS) motifs, to remove any inappropriate chemical structures and avoid false hits.

•    All compounds are available off the shelf. Pre-plates of 10 mM DMSO solutions, convenient to use.

•   NMR and HPLC validated to ensure high purity and quality.

产品详情

Product Details

•    A unique collection of natural product-like compound library.

•    Each molecule contains scaffold of natural products or has a Tanimoto similarity coefficient greater than 0.6 with 40K natural products, and natural-likeness scoring is more than -2.

•    Compatible with “Lipinski” s Rule of Five”, with multiple characteristics such as calculated good permeability (-3.2

•    Passed all associated MedChem filters, particularly pan assay interference compound (PAINS) motifs, to remove any inappropriate chemical structures and avoid false hits.

•    All compounds are available off the shelf. Pre-plates of 10 mM DMSO solutions, convenient to use.

•   NMR and HPLC validated to ensure high purity and quality.

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  •  化合物数量
  •  产品排布图
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  •  形式（固体或溶液）
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联系专家定制
  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack

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