2. 一站式药筛
  3. 化合物库
  4. 去甲肾上腺素转运体化合物库
去甲肾上腺素转运体化合物库 - Norepinephrine Transporter (NET) Compound Library

Cat. No.: HY-L906

2024年5月，Nature杂志在线发表了题为“Dimerization and antidepressant recognition at noradrenaline transporter”的研究论文，该研究成果由中国科学院上海药物研究所完成。该研究破解了重要神经系统疾病靶标——去甲肾上腺素转运体（NET），获得了人源NET同源二聚体分别与转运天然底物去甲肾上腺素NE，以及六种选择性抗抑郁药物的结合模式，为理解NET等单胺类转运体的生理调控机制奠定了重要的理论基础。

Norepinephrine Transporter (NET) Compound Library是基于HY-L901类药化合物库，通过计算机虚拟筛选获得，具体筛选流程包括分子对接筛选、关键药效团筛选以及CNS-MPO筛选，可用于靶向去甲肾上腺素转运体的新药发现。

我们将在明确您的产品用途后，向符合资质的客户通过定制合成服务的方式提供 MCE 去甲肾上腺素转运体化合物库，我们为该库中的所有产品提供溶液包装或粉末包装。溶液包装中，651 个产品以 10 mM 浓度提供。

溶液包装中，我们对于溶液状态稳定且溶解度不低于 10 mM 的产品，提供 10 mM 溶液。

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描述&特点

Biological Activity

•   A unique collection of 650 small molecules obtained by virtual screening targeting noradrenaline transporter for high throughput screening (HTS) and high content screening (HCS).

•   Compatible with “Lipinski” s Rule of Five”, with multiple characteristics such as calculated good permeability (-3.2

•   Passed all associated MedChem filters, particularly pan assay interference compound (PAINS) motifs, to remove any inappropriate chemical structures and avoid false hits.

•   All compounds are available off the shelf. Pre-plates of 10 mM DMSO solutions, convenient to use.

•   LCMS validated to ensure high purity and quality.

产品详情

Product Details

•   A unique collection of 650 small molecules obtained by virtual screening targeting noradrenaline transporter for high throughput screening (HTS) and high content screening (HCS).

•   Compatible with “Lipinski” s Rule of Five”, with multiple characteristics such as calculated good permeability (-3.2

•   Passed all associated MedChem filters, particularly pan assay interference compound (PAINS) motifs, to remove any inappropriate chemical structures and avoid false hits.

•   All compounds are available off the shelf. Pre-plates of 10 mM DMSO solutions, convenient to use.

•   LCMS validated to ensure high purity and quality.

产品资料

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  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack

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