2. 一站式药筛
  3. 化合物库
  4. 去甲肾上腺素转运体化合物库
去甲肾上腺素转运体化合物库 - Norepinephrine Transporter (NET) Compound Library

Cat. No.: HY-L906

2024年5月15日，Nature杂志在线发表了题为“Dimerization and antidepressant recognition at noradrenaline transporter”的研究论文，该研究成果由中国科学院上海药物研究所完成。该研究破解了重要神经系统疾病靶标——去甲肾上腺素转运体（NET），获得了人源NET同源二聚体分别与转运天然底物去甲肾上腺素NE，以及六种选择性抗抑郁药物的结合模式，为理解NET等单胺类转运体的生理调控机制奠定了重要的理论基础。

Norepinephrine Transporter (NET) Compound Library是基于HY-L901类药化合物库，通过计算机虚拟筛选获得，具体筛选流程包括分子对接筛选、关键药效团筛选以及CNS-MPO筛选，可用于靶向去甲肾上腺素转运体的新药发现。

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
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描述&特点

Biological Activity

1. A unique collection of 660 small molecules obtained by virtual screening targeting noradrenaline transporter for high throughput screening (HTS) and high content screening (HCS).

2. Compatible with “Lipinski” s Rule of Five”, with multiple characteristics such as calculated good permeability (-3.2

3. Passed all associated MedChem filters, particularly pan assay interference compound (PAINS) motifs, to remove any inappropriate chemical structures and avoid false hits.

4. All compounds are available off the shelf. Pre-plates of 10 mM DMSO solutions, convenient to use.

5. LCMS validated to ensure high purity and quality.

产品详情

Product Details

Formulation: A collection of 660 Natural product-like and Lead-like compounds supplied as pre-dissolved solutions.

Solution: 660 compounds supplied in 10 mM solution.

Container: 96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube with Screw Cap and Optional 2D Barcode.

Storage: -80°C

Shipping: Blue ice

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  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack

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