2. Anti-infection Autophagy Apoptosis MAPK/ERK Pathway Cytoskeleton Cell Cycle/DNA Damage
  3. Fungal Autophagy Apoptosis p38 MAPK Microtubule/Tubulin
  4. Sertaconazole

Sertaconazole  (Synonyms: 舍他康唑; FI7056 free base)

目录号: HY-B0736
产品使用指南 技术支持

Sertaconazole (FI7056 free base) 是一种局部广谱的抗真菌剂，可通过激活 p38-COX-2-PGE 2 通路来发挥抗炎活性。Sertaconazole 也是一种微管蛋白抑制剂，具有抗癌细胞增殖活性，诱导细胞的凋亡和自噬，还能抑制细胞的迁移，具有较好的抗癌活性。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Sertaconazole Chemical Structure

Sertaconazole Chemical Structure

CAS No. : 99592-32-2

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Sertaconazole 的其他形式现货产品:

Customer Review

Other Forms of Sertaconazole:

Sertaconazole 相关抗体

Top Publications Citing Use of Products

查看 p38 MAPK 亚型特异性产品:

查看所有亚型
p38 MAPK p38α p38β MAPK13 p38δ p38γ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Sertaconazole (FI7056 free base) is a broad-spectrum topical antifungal agent, exhibits anti-inflammatory activity via activation of a p38-COX-2-PGE2 pathway. Sertaconazole is also a microtubule inhibitor, shows antiproliferative effect, induces apoptosis and autophagy, and can also inhibit the migration of cells[1][2][3][4].

体外研究
(In Vitro)

Sertaconazole (0.03-40 µg/mL; 24 h) inhibits 150 strains of yeasts which includes six Candida species with arithmetic mean MIC of 0.77 µg/mL[1].
Sertaconazole (1 µg/mL; 5, 10, 30, 60 min) activates p38 MAP kinase in a time-dependent manner[2].
Sertaconazole (1, 2 µg/mL; 6, 8, or 24 h) increases a twofold release of PGE2 via COX-2 in keratinocytes, which is dependent on p38 activation[2].
Cetaconazole (10, 20, 30, 40 µM; 24 h) induces strong mitotic arrest by depolymerizing interphase and spindle microtubules, thereby inducing chromosome aggregation defects and causing anti-proliferation effect[3].
Sertaconazole (20, 40 µM; 24 h) induces apoptosis through p53 pathway in HeLa cells[3].
Sertaconazole (20, 30 µM; 24, 48, and 72 h) inhibits the migration of HeLa cells in a concentration-dependent manner[3].
Sertaconazole (15, 30 µM; 24 h) induces autophagy in A549, H460 cells[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Sertaconazole 相关抗体:

Cell Viability Assay[1]

Cell Line: C. albicans, C. guilliermondii, C. krusei, C. parapsilosi, C. tropicalis, C. glabrata
Concentration: 0.03-40 µg/m
Incubation Time: 24 h
Result: Againsted 150 strains of yeasts (six Candida species) which included C. albicans, C. guilliermondii, C. krusei, C. parapsilosi, C. tropicalis, C. glabrata species with arithmetic mean MIC values of 1.02, 0.51, 0.38, 0.31, 1.67 and 0.78 µg/mL, respectively.

Western Blot Analysis[2]

Cell Line: HaCaT cells
Concentration: 1 µg/mL
Incubation Time: 5, 10, 30, 60 min
Result: Showed activity of activating p38 MAP kinase and Hsp27 in a time-dependent manner.

Western Blot Analysis[2]

Cell Line: HaCaT cells
Concentration: 1, 2 µg/mL
Incubation Time: 6 or 8 h
Result: Induced 50% expression of COX-2 and resulted in a twofold increased in PGE2 release.

Western Blot Analysis[2]

Cell Line: siRNA-transfected HaCaT cells (without p38 MAP kinase expression)
Concentration: 1 µg/mL
Incubation Time: 24 h
Result: Mediated induction of PGE2 was dependent on p38 activation.

Cell Proliferation Assay[3]

Cell Line: HeLa, HEK-293, MCF-7, A549 cells
Concentration: 0-100 µM
Incubation Time: 24 h
Result: Showed antiproliferation activity with IC50s of 38, 45.1, 41.5, and 40.8 μM for HeLa, HEK-293, A549, and MCF-7 cells, respectively.
Exhibited mitotic block activity and induced cell death at concentration above 30 μM, but no significant increased in the number of mitotic cells.
Depolymerized interphase and spindle microtubules inducing defect in chromosomal congression.

Apoptosis Analysis[3]

Cell Line: HeLa cells
Concentration: 10, 20, 40 µM
Incubation Time: 24 h
Result: Induced approximately 5%, 10%, and 21% cells apoptotic at concentrations of 10, 20 and 40 μM, respectively.

Western Blot Analysis[3]

Cell Line: A549 cells
Concentration: 20, 40 µM
Incubation Time: 24 h
Result: Induced apoptosis through p53 pathway that the expression of p53 from 30% to 50% and 95% and p21 from 11 to 39% and 40% respectively.
Resulted in Noxa and Puma, two direct transcriptional targets of p53 to be overexpressed.

Cell Migration Assay [3]

Cell Line: HeLa cells
Concentration: 20, 30 µM
Incubation Time: 24, 48, and 72 h
Result: Inhibited the migration of HeLa cells at concentrations lesser than its IC50, which in a concentration-dependent manner.

Cell Autophagy Assay[4]

Cell Line: A549, H460 cells
Concentration: 15, 30 µM
Incubation Time: 24 h
Result: Increased endogenous LC3 puncta and LC3 intensity, which indicated induction of autophagy in A549 and H460 cells.
体内研究
(In Vivo)

Sertaconazole (1% (w/v); apply to the left ear, once) suppresses of TPA-induced ear edema CD-1 mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CD-1 mice (TPA-induced ear edema model)[2].
Dosage: 1% (w/v)
Administration: Apply to the left ear, once.
Result: Exhibited a significant reduction of inflammation in mice by mediating PGE2 release.
Clinical Trial
分子量

437.77

Formula

C20H15Cl3N2OS
CAS 号
中文名称

舍他康唑
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Sertaconazole 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sertaconazole99592-32-2FI7056舍他康唑FI 7056FI-7056FungalAutophagyApoptosisp38 MAPKMicrotubule/TubulinCandidaPGE2COX-2HaCaTHeLaHEK-293MCF-7A549Inhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Sertaconazole
目录号：
HY-B0736
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z