2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. SFOM-0046

SFOM-0046 可以使细胞周期停滞在 S 期，并引起 DNA 复制应激，导致 H2AX 磷酸化为 γ-H2AX。SFOM-0046 会诱导 DNA 损伤。SFOM-0046 是一种有效的抗癌剂。

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SFOM-0046 Chemical Structure

SFOM-0046 Chemical Structure

CAS No. : 1383607-61-1

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SFOM-0046 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SFOM-0046 arrests cell cycle in S-phase and causes DNA replication stress leading to the phosphorylation of H2AX into γ-H2AX. SFOM-0046 induces DNA damages. SFOM-0046 is a potent anticancer agent[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HT-1080 IC50
0.36 μM
Compound: SFOM-0046
Antiproliferative activity against human HT1080 cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B assay
Antiproliferative activity against human HT1080 cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B assay
[PMID: 26408815]
HT-1080 IC50
0.45 μM
Compound: SFOM-0046
Antiproliferative activity against human HT-1080 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
Antiproliferative activity against human HT-1080 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
[PMID: 33007554]
HT-1080 IC50
7.4 μM
Compound: SFOM-0046
Antiproliferative activity against human HT-1080 cells assessed as cell growth inhibition measured after 48 hrs in presence of uridine by SRB assay
Antiproliferative activity against human HT-1080 cells assessed as cell growth inhibition measured after 48 hrs in presence of uridine by SRB assay
[PMID: 33007554]
HT-29 IC50
0.99 μM
Compound: SFOM-0046
Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
[PMID: 33007554]
HT-29 IC50
12 μM
Compound: 46
Cytotoxicity against human HT-29 cells after 48 hrs by SRB assay
Cytotoxicity against human HT-29 cells after 48 hrs by SRB assay
[PMID: 22694057]
HT-29 IC50
12 μM
Compound: SFOM-0046
Antiproliferative activity against human HT-29 cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B assay
Antiproliferative activity against human HT-29 cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B assay
[PMID: 26408815]
HT-29 IC50
27 μM
Compound: SFOM-0046
Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition measured after 48 hrs in presence of uridine by SRB assay
Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition measured after 48 hrs in presence of uridine by SRB assay
[PMID: 33007554]
M21 IC50
2.5 μM
Compound: 46
Cytotoxicity against human M21 cells after 48 hrs by SRB assay
Cytotoxicity against human M21 cells after 48 hrs by SRB assay
[PMID: 22694057]
M21 IC50
2.5 μM
Compound: SFOM-0046
Antiproliferative activity against human M21 cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B assay
Antiproliferative activity against human M21 cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B assay
[PMID: 26408815]
M21 IC50
3 μM
Compound: SFOM-0046
Antiproliferative activity against human M21 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
Antiproliferative activity against human M21 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
[PMID: 33007554]
M21 IC50
30 μM
Compound: SFOM-0046
Antiproliferative activity against human M21 cells assessed as cell growth inhibition measured after 48 hrs in presence of uridine by SRB assay
Antiproliferative activity against human M21 cells assessed as cell growth inhibition measured after 48 hrs in presence of uridine by SRB assay
[PMID: 33007554]
MCF7 IC50
18 μM
Compound: SFOM-0046
Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition measured after 48 hrs in presence of uridine by SRB assay
Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition measured after 48 hrs in presence of uridine by SRB assay
[PMID: 33007554]
MCF7 IC50
3.4 μM
Compound: 46
Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
[PMID: 22694057]
MCF7 IC50
3.4 μM
Compound: SFOM-0046
Antiproliferative activity against human MCF7 cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B assay
Antiproliferative activity against human MCF7 cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B assay
[PMID: 26408815]
MCF7 IC50
5.9 μM
Compound: SFOM-0046
Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
[PMID: 33007554]
Panel colon cells IC50
1.5 μM
Compound: SFOM-0046
Antiproliferative activity against human Panel colon (Carcinoma cell lines) assessed as cell growth inhibition measured after 48 hrs by SRB assay
Antiproliferative activity against human Panel colon (Carcinoma cell lines) assessed as cell growth inhibition measured after 48 hrs by SRB assay
[PMID: 33007554]
Panel leukemia cells IC50
0.81 μM
Compound: SFOM-0046
Antiproliferative activity against human Panel leukemia (Carcinoma cell lines) assessed as cell growth inhibition measured after 48 hrs by SRB assay
Antiproliferative activity against human Panel leukemia (Carcinoma cell lines) assessed as cell growth inhibition measured after 48 hrs by SRB assay
[PMID: 33007554]
Panel NCI-60 cells IC50
3.5 μM
Compound: SFOM-0046
Antiproliferative activity against human Panel NCI-60 (60 carcinoma cell lines) assessed as cell growth inhibition measured after 48 hrs by SRB assay
Antiproliferative activity against human Panel NCI-60 (60 carcinoma cell lines) assessed as cell growth inhibition measured after 48 hrs by SRB assay
[PMID: 33007554]
分子量

348.42

Formula

C17H20N2O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SFOM-0046 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SFOM-00461383607-61-1SFOM0046SFOM 0046DNA/RNA Synthesiscell cycleS-phaseDNA replicationH2AXγ-H2AXanticancerInhibitorinhibitorinhibit

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