2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. SGS518 oxalate

SGS518 oxalate 是一种选择性的 5-HT6R 的拮抗剂。SGS518 oxalate 可用于研究认知障碍，例如健忘症，焦虑症和抑郁症等，并且在高剂量时可有效保护小鼠视网膜。

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SGS518 oxalate Chemical Structure

SGS518 oxalate Chemical Structure

CAS No. : 445441-27-0

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SGS518 oxalate 相关抗体

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查看 5-HT Receptor 亚型特异性产品:

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5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SGS518 oxalate is a selective 5-HT6R antagonist. SGS518 oxalate can be used for the research of cognitive impairments such as amnesia, anxiety and depression, and it is effective in protecting mouse retina at high doses[1]

IC50 & Target

5-HT6 Receptor

 

体内研究
(In Vivo)

SGS518 oxalate (30 mg/kg; i.p. for 30 min) protects Abca4–/–Rdh8 sup>–/– mouse retinas from light-induced damage[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Abca4–/–Rdh8 sup>–/–mice are exposed at white light[1]
Dosage: 30 mg/kg
Administration: I.p. injection for 30 minutes
Result: A marked preservation of the photoreceptor layer.
Reduced formation of autofluorescent spots in mice.
Protected retinal morphology.
分子量

510.51

Formula

C23H24F2N2O7S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SGS518 oxalate 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SGS518445441-27-0SGS 518SGS-5185-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptor5-HT6RcognitiveimpairmentsamnesiaanxietydepressionretinaInhibitorinhibitorinhibit

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产品名称：
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目录号：
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