2. Metabolic Enzyme/Protease
  3. Isocitrate Dehydrogenase (IDH)
  4. SH1573

SH1573 是一种具有口服活性的 mIDH2 抑制剂。SH1573 对 mIDH2 R140Q 蛋白具有较强的选择性抑制作用 (IC50=4.78 nmol/L)，可有效降低动物模型、细胞系、血清和肿瘤中致癌代谢物 2-羟基戊二酸 (2-HG) 的产生。SH1573 可用于急性髓性白血病 (AML) 的研究。

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SH1573 Chemical Structure

SH1573 Chemical Structure

CAS No. : 2376068-96-9

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SH1573 相关抗体

Top Publications Citing Use of Products

查看 Isocitrate Dehydrogenase (IDH) 亚型特异性产品:

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IDH1 IDH2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SH1573 is an orally active mIDH2 inhibitor. SH1573 has a strong and selective inhibitory effect on mIDH2 R140Q protein (IC50=4.78 nmol/L), and can effectively reduce the production of the carcinogenic metabolite 2-hydroxyglutarate (2-HG) in animal models, cell lines, serum and tumors. SH1573 can be used for the study of acute myeloid leukemia (AML)[1].

分子量

635.46

Formula

C21H18F9N7O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SH1573 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SH15732376068-96-9SH 1573SH-1573Isocitrate Dehydrogenase (IDH)InhibitorAMLisocitrate dehydrogenasemutant2-HGinhibitorinhibit

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目录号：
HY-164526
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