2. Anti-infection
  3. SARS-CoV
  4. SIMR3030

SIMR3030 是一种有效的 SARS-CoV-2 PLpro 抑制剂，IC50 值为 0.0399 µg/mL。SIMR3030 显示出抗病毒活性。SIMR3030 降低 SARS-CoV spike、ORF1b、IFN-α、IL-6 mRNA 表达。SIMR3030 在小鼠中表现出较好的安全性。

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SIMR3030 Chemical Structure

SIMR3030 Chemical Structure

CAS No. : 2708270-99-7

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规格 是否有货
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SIMR3030 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SIMR3030 is a potent SARS-CoV-2 PLpro inhibitor with an IC50 value of 0.0399 µg/mL. SIMR3030 shows antiviral activity. SIMR3030 decreases SARS-CoV spike, ORF1b, IFN-α, IL-6 mRNA expression. SIMR3030 exhibits a satisfactory safety profile in mice[1].

IC50 & Target

IC50: 0.0399 µg/mL (SARS-CoV-2 PLpro)[1]
体外研究
(In Vitro)

SIMR3030 (0-100 µg/mL) 显示抗病毒活性，对 SARS-CoV-2 和 MERS-CoV 的 IC50 值分别为 12.1、6.206 μg/mL[1]。
SIMR3030 (20 µg/mL; 1, 6, 12 h) 降低 Caco-2 细胞中的 SARS-CoV spike、ORF1b、IFN-α、IL-6 mRNA 表达水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SIMR3030 相关抗体:

RT-PCR[1]

Cell Line: Caco-2 cells (SARS-CoV-2 RNA infected)
Concentration: 20 μg/mL
Incubation Time: 1, 6, 12 h
Result: Decreased SARS-CoV spike and ORF1b mRNA expression levels, reduced the mRNA expression of IFN-α at 1 and 3 h , IL-6 and OAS1 at 1, 3 and 12 h.
体内研究
(In Vivo)

SIMR3030 (25、50、100 mg/kg；I.p.；每日一次，持续 14 天) 在实验小鼠模型中表现出较好的安全性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 18-25 g, adult female Balb/c mice[1]
Dosage: 25, 50, 100 mg/kg
Administration: I.p.; daily for 14 days
Result: Showed no signs of toxicity or weight loss were noticed during 12.5 and 25 mg/kg multiple-dose studies for 14 days, no signs of toxicity or weight loss were noticed during 12.5 and 25 mg/kg multiple-dose studies for 14 days.
分子量

427.54

Formula

C27H29N3O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SIMR3030 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SIMR30302708270-99-7SIMR 3030SIMR-3030SARS-CoVSARS coronavirusCaco-2 cellsantiviralSARS-CoV spikeORF1bIFN-αIL-6Inhibitorinhibitorinhibit

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目录号：
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