2. Anti-infection Apoptosis
  3. Bacterial Apoptosis
  4. Siomycin A

Siomycin A  (Synonyms: 盐霉素 A)

目录号: HY-P1687
产品使用指南

摩尔计算器

Siomycin A 是一种硫肽抗生素，也是一种 Forkhead box M1(FOXM1) 选择性抑制剂，而且不影响 Forkhead box 家族其他成员。Siomycin A 具有抗肿瘤作用并促进细胞凋亡。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Siomycin A Chemical Structure

Siomycin A Chemical Structure

CAS No. : 12656-09-6

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
500 μg ￥8550
3 - 4 周

* Please select Quantity before adding items.

Customer Review

Siomycin A 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Siomycin A is a thiopeptide antibiotic and is a Forkhead box M1(FOXM1) selective inhibitor without affecting other members of the Forkhead box family. Siomycin A has anti-tumor and promotes apoptosis[1][2].

IC50 & Target

Forkhead box M1(FOXM1)[1]
体外研究
(In Vitro)

Siomycin A (0-10 µM; 24-72 hours; K562, MCF7 and MiaPaCa-2 cells) treatment markedly reduces cell viability in a dose-dependent and a time-dependent association in K562, MCF7 and MiaPaCa-2 cells. Among the three cell lines, the IC50 of the human leukemia K562 cells is the lowest at 6.25 µM at 24 h, while that for the human pancreatic cancer MiaPaCa-2 cells is 6.38 µM. However, the IC50 of the human pancreatic cancer MiaPaCa-2 cells at 48 and 72 h are the lowest of the three cell lines, which are 0.76 and 0.54 µM, respectively[1].
Siomycin A (0-10 µM; MiaPaCa-2 cells) treatment has potent proapoptotic effect in MiaPaCa-2 cells[1].
Siomycin A (0-10 µM; 24 hours; MiaPaCa-2 cells) treatment significantly reduces the expression levels of MMP-2, MMP-9 and α-tubulin protein in the MiaPaCa-2 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Siomycin A 相关抗体:

Cell Viability Assay[1]

Cell Line: K562, MCF7 and MiaPaCa-2 cells
Concentration: 0 µM, 0.625 µM, 1.25 µM, 2.5 µM, 5 µM or 10 µM
Incubation Time: 24, 48 and 72 hours
Result: Cell viability was markedly reduced in a dose-dependent and a time-dependent association.

Apoptosis Analysis[1]

Cell Line: MiaPaCa-2 cells
Concentration: 0 µM, 0.625 µM, 1.25 µM, 2.5 µM, 5 µM or 10 µM
Incubation Time:
Result: Promoted apoptosis of MiaPaCa-2 cells.

Western Blot Analysis[1]

Cell Line: MiaPaCa-2 cells
Concentration: 0 µM, 0.625 µM, 1.25 µM, 2.5 µM, 5 µM or 10 µM
Incubation Time: 24 hours
Result: The expression levels of MMP-2 and MMP-9 protein in the MiaPaCa-2 cells were significantly reduced in the 2.5, 5 and 10 µM groups.
体内研究
(In Vivo)

Siomycin A (1 µM; subcutaneous injection; for 4 weeks; male Balb/c nude mice) pretreatment decreases tumour growth in an in vivo mouse model[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Four- to five-week old male Balb/c nude mice with IOMM-LEE cells[2]
Dosage: 1 µM-pretreated IOMM-Lee cells
Administration: Subcutaneous injection; for 4 weeks
Result: Decreased tumour growth in an in vivo mouse model.
分子量

1648.84

Formula

C71H81N19O18S5
CAS 号
中文名称

盐霉素 A
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Siomycin A 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Siomycin A12656-09-6盐霉素 ABacterialApoptosisInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Siomycin A
目录号：
HY-P1687
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z