2. Immunology/Inflammation
  3. CD2
  4. Siplizumab

Siplizumab  (Synonyms: MEDI-507)

目录号: HY-P99904 纯度: 99.83%
COA

摩尔计算器

Siplizumab (MEDI-507) 是一种抗 CD2 的人源化 IgG1 单克隆抗体。Siplizumab 可耗尽 T 细胞、降低 T 细胞活化、抑制 T 细胞增殖并富集 naïve 和 bona fide 调节性 T 细胞。

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CAS No. : 288392-69-8

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规格 价格 是否有货 数量
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5 mg ￥7800
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Siplizumab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Siplizumab (MEDI-507) is a humanized IgG1 monoclonal antibody against CD2. Siplizumab depletes T cells, decreases T cell activation, inhibites T cell proliferation and enriches naïve and bona fide regulatory T cells[1].

同型

Human IgG1 kappa
推荐同型对照抗体
种属

Humanized
体外研究
(In Vitro)

Siplizumab (MEDI-507; 0.00001-10 nM) 结合 FcγR 并诱导信号转导[1]。
Siplizumab (0.0001-10 μg/mL) 介导细胞耗竭并降低 T 细胞增殖[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Siplizumab 相关抗体:
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Biological Activity
  • Immobilized Human CD2 Protein (ECD, His Tag) can bind Siplizumab. The EC50 for this effect is 1.441 ng/mL.
  • Loaded Siplizumab on AHC2 biosensor, can bind CD2 Protein, Human (HEK293, His, HY-P7882) with an affinity constant of 3.775E-09 M as determined in BLI assay.
纯度 & 产品资料
参考文献

Siplizumab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Siplizumab288392-69-8MEDI-507MEDI507MEDI 507CD2Cluster of differentiation 2monoclonal antibodyIgG1cancerT-cellInhibitorinhibitorinhibit

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