2. Stem Cell/Wnt
  3. Wnt β-catenin
  4. SKL2001 (GMP)

SKL2001 (GMP) 是 GMP 级别的 SKL2001 (HY-101085)。SKL2001 是 Wnt/β-catenin 信号通路的激动剂，具有抗肿瘤活性。SKL2001 通过破坏 Axin/β-catenin 相互作用，稳定细胞内 β-catenin。

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SKL2001 (GMP) Chemical Structure

SKL2001 (GMP) Chemical Structure

CAS No. : 909089-13-0

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SKL2001 (GMP) 的其他形式现货产品:

Other Forms of SKL2001 (GMP):

SKL2001 (GMP) 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 45 篇科研文献

WB

    SKL2001 (GMP) purchased from MCE. Usage Cited in: Mol Ther Nucleic Acids. 2020 Jun 27;21:577-591.  [Abstract]

    Western blotting confirmed that β-catenin signaling is activated after GC cells are cultured with SKL2001 (40 μM), accompanied by the enhanced expression of the downstream molecules Cyclin D1, c-Myc, and nuclear β-catenin in BGC-823 cells.

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    SKL2001 (GMP) is SKL2001 (HY-101085) produced by using GMP guidelines. SKL2001 is an agonist of the Wnt/β-catenin pathway, with anti-cancer activity. SKL2001 stabilizes intracellular β-catenin via disruption of the Axin/β-catenin interaction[1].

    IC50 & Target

    Wnt/β-catenin[1]
    体外研究
    (In Vitro)

    SKL2001 is an agonist of the Wnt/β-catenin pathway, and also upregulates the expression of Axin2, a downstream target of the Wnt/β-catenin pathway, but shows no effect on NF-κB, p53 reporter activity and GSK-3β activity. SKL2001 causes osteoblast differentiation (20 and 40 μM) and suppresses preadipocyte differentiation (5, 10, and 30 μM) via the activation of the Wnt/β-catenin pathway. SKL2001 (5, 10, and 30 μM) stabilizes intracellular β-catenin in 3T3-L1 cells[1]. SKL2001 (40 μM) significantly inhibits the proliferation of HCT116 spheroids independently of cytotoxicity and the inhibition is reversible; SKL2001 cuases cell cycle arrest in HCT116 spheroids. SKL2001 (40 μM) enhances round-shape spheroid formation and E-cadherin expression[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    SKL2001 (GMP) 相关抗体:
    分子量

    286.29

    Formula

    C14H14N4O3
    CAS 号
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    SKL2001 (GMP) 相关分类

    • 摩尔计算器

    • 稀释计算器

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    SKL2001 (GMP)909089-13-0Wntβ-cateninBeta cateninInhibitorinhibitorinhibit

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    目录号：
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