2. Neuronal Signaling
  3. OLIG2
  4. SKOG102

SKOG102 是一种有效的 OLIG2 抑制剂，可直接与 OLIG2 结合并干扰 OLIG2 结合 DNA 的能力。SKOG102 可用于胶质母细胞瘤 (GBM) 的研究。

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SKOG102 Chemical Structure

SKOG102 Chemical Structure

CAS No. : 21062-28-2

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SKOG102 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SKOG102 is a potent OLIG2 inhibitor that is directly engaging OLIG2 and interferes with the ability of OLIG2 to bind DNA. SKOG102 can be used for the research of glioblastoma (GBM)[1].

IC50 & Target

OLIG2[1]
体外研究
(In Vitro)

SKOG102 (0.1-5 μM; 72 h) 抑制人 GBM4 和 GBM8 细胞生长为神经球，IC50 分别为 10.66 和 1.536 μM[1]。
SKOG102 (0.5-5 μM; 12 h) 增加 GBM4 细胞中的 p21 RNA 水平并降低 OMG RNA 水平[1]。
SKOG102 (5 μM; 20 h) 抑制 OLIG2-DNA 结合，并降低 GBM8 细胞中的丝氨酸磷酸化 OLIG2 和总 OLIG2 蛋白水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SKOG102 相关抗体:
体内研究
(In Vivo)

SKOG102 (10-20 mg/kg; i.p.) 抑制小鼠 GBM4 肿瘤的生长[1]。
SKOG102 (5 mg/kg; i.p.) 即使在相对较短的时间内也会在肿瘤中积聚，注射小鼠后 4 小时血浆和脑浓度几乎相同[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NSG mice were inoculated in each flank with GBM4 cells[1]
Dosage: 10, 15, and 20 mg/kg; dissolved in solutol:PEG400:water (20%:40%:40%)
Administration: Intraperitoneal injection; first 2 weeks (from day 33 to 46) 10 mg/kg, third week (from day 47 to 54) 15 mg/kg, fourth week (from 55 to 66) first 3 days 20 mg/kg, 2 days break, then alternate days from day 60 to 66
Result: Significantly attenuated tumor growth.
分子量

422.35

Formula

C19H25Cl2N7
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SKOG102 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SKOG10221062-28-2SKOG 102SKOG-102OLIG2Oligodendrocyte Transcription Factor 2DNAglioblastomaGBMInhibitorinhibitorinhibit

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