1. Immunology/Inflammation
  2. Interleukin Related
  3. SMA-12b

SMA-12b 是一种寄生蠕虫化合物 ES-62 的小分子类似物。SMA-12b 具有免疫调节活性,通过调节多种炎症反应基因的表达,尤其是与炎症体相关的基因,来发挥作用。SMA-12b 显著降低了与炎症体相关的细胞因子 IL-1β 的表达,并能够通过 NRF2 介导的机制抑制 IL-1β 的产生。SMA-12b 可用于类风湿关节炎 (RA) 和其他自身免疫性疾病的研究。

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SMA-12b Chemical Structure

SMA-12b Chemical Structure

CAS No. : 1496553-39-9

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SMA-12b is a small molecule analogue of the parasitic worm compound ES-62. SMA-12b has immunomodulatory activity, acting by regulating the expression of multiple inflammatory response genes, especially those associated with inflammatory bodies. SMA-12b significantly reduces the expression of cytokine IL-1β associated with inflammatory bodies and inhibites the production of IL-1β through a mechanism mediated by NRF2. SMA-12b can be used in the study of rheumatoid arthritis (RA) and other autoimmune diseases[1].

分子量

383.29

Formula

C13H22INO2S

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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SMA-12b
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HY-137007
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