2. Immunology/Inflammation
  3. Interleukin Related
  4. SMA-12b

SMA-12b 是一种寄生蠕虫化合物 ES-62 的小分子类似物。SMA-12b 具有免疫调节活性，通过调节多种炎症反应基因的表达，尤其是与炎症体相关的基因，来发挥作用。SMA-12b 显著降低了与炎症体相关的细胞因子 IL-1β 的表达，并能够通过 NRF2 介导的机制抑制 IL-1β 的产生。SMA-12b 可用于类风湿关节炎 (RA) 和其他自身免疫性疾病的研究。

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SMA-12b Chemical Structure

SMA-12b Chemical Structure

CAS No. : 1496553-39-9

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SMA-12b 相关抗体

Top Publications Citing Use of Products

查看 Interleukin Related 亚型特异性产品:

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SMA-12b is a small molecule analogue of the parasitic worm compound ES-62. SMA-12b has immunomodulatory activity, acting by regulating the expression of multiple inflammatory response genes, especially those associated with inflammatory bodies. SMA-12b significantly reduces the expression of cytokine IL-1β associated with inflammatory bodies and inhibites the production of IL-1β through a mechanism mediated by NRF2. SMA-12b can be used in the study of rheumatoid arthritis (RA) and other autoimmune diseases[1].

分子量

383.29

Formula

C13H22INO2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SMA-12b 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SMA-12b1496553-39-9Interleukin RelatedILInflammatory bodyRAautoimmune diseasecytokinesInhibitorinhibitorinhibit

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