Sodium butyrate  (Synonyms: Butanoic acid (sodium); Butyric acid (sodium))

Sodium butyrate (GMP) refers to Sodium butyrate (HY-B0350A) of GMP grade. Small molecules of GMP grade can be used as adjuvants in cell therapy. Sodium Butyrate (sodium butanoate) is an inhibitor of HDAC, possessing anti-tumor activity^{[1][2][3][4][5]}.

Sodium Butyrate (GMP) 可诱导鼻咽癌细胞的形态变化、抑制细胞增殖并削弱细胞活力。Sodium Butyrate (GMP) (1、5、10 mM) 对鼻咽癌细胞具有细胞毒性，在 5-8F 和 6-10B 细胞中均诱导剂量和时间依赖性的细胞活力下降。Sodium Butyrate (GMP) 通过激活线粒体凋亡轴诱导鼻咽癌细胞凋亡。此外，SOCE 抑制和 CRAC 通道破坏可减弱Sodium Butyrate (GMP) 诱导的细胞凋亡^[1]。
Sodium Butyrate (GMP) 显著降低细胞活力，同时降低 p-mTOR 和 PCNA 蛋白水平。Sodium Butyrate (GMP) 以剂量依赖性方式诱导细胞周期停滞在 G0/G1 期，并减少 S 期细胞数量。此外，较高浓度的 Sodium Butyrate (GMP) (1、5、10 mM) 可增加 p21、p27 和促凋亡 bak 基因的相对表达以及 p21Waf1/Cip1、p27Kip1、cyclinD3、CDK4 和 Cleave-caspase3 的蛋白水平，而 5 和 10 mM Butyrate 可降低 cyclinD1 和 CDK6 的水平^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

与未治疗的动物相比，HI 后立即给予 Sodium Butyrate (GMP) (300 mg/kg，皮下) 可提供几乎完全的神经保护。给予 Sodium Butyrate (GMP) 会导致同侧小胶质细胞数量增加至接受载体治疗的动物的 150%。Sodium Butyrate (GMP) 促进新生儿缺氧缺血后小胶质细胞从 M1 型极化为 M2 型表型^[2]。
Sodium Butyrate (GMP) (300 mg/kg，皮下) 与 AK-7 (20 mg/kg，腹腔注射) 组合可显著缓解小鼠探索新物体时间的减少，改善小鼠齿状回中 Ki67 阳性细胞和 DCX 免疫反应性神经母细胞数量的减少。此外，Sodium Butyrate (GMP) 可逆转 SIRT2 相关的年龄表型^[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

110.09

C₄H₇NaO₂

156-54-7

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Huang W, et al. Inhibition of store-operated Ca2+ entry counteracts the apoptosis of nasopharyngeal carcinoma cells induced by sodium butyrate. Oncol Lett. 2017 Feb;13(2):921-929  [Content Brief]

  [2]. Wang P, et al. Sodium butyrate triggers a functional elongation of microglial process via Akt-small RhoGTPase activation and HDACs inhibition. Neurobiol Dis. 2017 Dec 14;111:12-25.  [Content Brief]

  [3]. Jaworska J, et al. The potential neuroprotective role of a histone deacetylase inhibitor, sodium butyrate, after neonatal hypoxia-ischemia. J Neuroinflammation. 2017 Feb 10;14(1):34  [Content Brief]

  [4]. Qiu Y, et al. Effect of sodium butyrate on cell proliferation and cell cycle in porcine intestinal epithelial (IPEC-J2) cells. In Vitro Cell Dev Biol Anim. 2017 Jan 27  [Content Brief]

  [5]. Jung HY, et al. Sirtuin-2 inhibition affects hippocampal functions and sodium butyrate ameliorates the reduction in novel object memory, cell proliferation, and neuroblast differentiation. Lab Anim Res. 2016 Dec;32(4):224-230  [Content Brief]