2. Apoptosis Metabolic Enzyme/Protease Anti-infection
  3. MDM-2/p53 E1/E2/E3 Enzyme Fungal Apoptosis
  4. Solasodine hydrochloride

Solasodine hydrochloride  (Synonyms: Purapuridine hydrochloride; Solancarpidine hydrochloride; Solasodin hydrochloride)

目录号: HY-W751400
产品使用指南

摩尔计算器

Solasodine (Purapuridine) hydrochloride 是一种存在于茄科植物中的甾体生物碱。Solaso​​dine hydrochloride 通过抑制 p53-MDM2 复合物、p21Waf1/Cip1 和 Bcl-2 蛋白来诱导细胞凋亡 (apoptosis)。Solaso​​dine hydrochloride 具有神经保护、抗真菌、降压、抗癌、抗动脉粥样硬化、抗雄激素和抗炎活性。

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Solasodine hydrochloride Chemical Structure

Solasodine hydrochloride Chemical Structure

CAS No. : 6106-33-8

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Solasodine hydrochloride 的其他形式现货产品:

Other Forms of Solasodine hydrochloride:

Solasodine hydrochloride 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Solasodine (Purapuridine) hydrochloride is a steroidal alkaloid that occurs in plants of the Solanaceae family. Solasodine hydrochloride induces apoptosis by inhibiting the p53-MDM2 complex, p21Waf1/Cip1, and Bcl-2 proteins. Solasodine hydrochloride has neuroprotective, antifungal, hypotensive, anticancer, antiatherosclerotic, antiandrogenic and anti-inflammatory activities[1][2][3].

体外研究
(In Vitro)

Solaso​​dine（90 μM；2 天）hydrochloride 治疗显示 P19 细胞中出现明显发芽。Solaso​​dine hydrochloride 诱导所研究的不同神经元标志物的强烈表达，包括 βIII-微管蛋白、突触素、MAP2、ChAT 和神经母细胞标志物双皮质素。Solaso​​dine hydrochloride 诱导 P19 细胞分化，主要是向神经通路分化[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Solasodine hydrochloride 相关抗体:
体内研究
(In Vivo)

Solaso​​dine（25-100 mg/kg；腹膜内注射；一次）hydrochloride 治疗显著延迟 PCT 诱发的抽搐中后肢强直伸肌 (HLTE) 期的潜伏期。并以剂量依赖性方式显著增强硫喷妥钠诱发的睡眠。 Solaso​​dine hydrochloride 具有抗惊厥和抑制中枢神经系统的作用[2]。
Solaso​​dine（375 μM；侧脑室注射；持续 2 周）hydrochloride 治疗可显著增加室管膜层、脑室下区和皮质细胞对溴脱氧尿苷的摄取，这些细胞与双皮质素免疫染色共定位。Solaso​​dine hydrochloride 对大鼠的治疗可显著增加室管膜细胞中胆固醇和药物结合转运蛋白的表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Swiss albino mice (18-25 g) treated with Picrotoxin (PCT) or Thiopental[2]
Dosage: 25 mg/kg, 50 mg/kg and 100 mg/kg
Administration: Intraperitoneal injection; once
Result: Significantly delayed latency of hind limb tonic extensor (HLTE) phase in the PCT-induced convulsions. And significantly potentiated Thiopental-provoked sleep in a dose-dependent manner.
分子量

450.10

Formula

C27H44ClNO2
CAS 号
中文名称

盐酸茄索定
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Solasodine hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Solasodine6106-33-8PurapuridineSolancarpidineSolasodin盐酸茄索定MDM-2/p53E1/E2/E3 EnzymeFungalApoptosisE1 activating enzymeE2 conjugating enzymeE3 ligating enzymeUbiquitin activating enzymeUbiquitin conjugating enzymeUbiquitin ligasesteroidal alkaloidapoptosisp53-MDM2 complexp21Waf1/Cip1Bcl-2 proteinseuroprotectiveantifungalhypotensiveanticancerantiatheroscleroticantiandrogenic and anti-inflammatory activitiesInhibitorinhibitorinhibit

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