2. MAPK/ERK Pathway Protein Tyrosine Kinase/RTK Autophagy Apoptosis
  3. Raf VEGFR FLT3 Autophagy Ferroptosis Apoptosis
  4. Sorafenib (Tosylate) (Standard)

Sorafenib (Tosylate) (Standard)  (Synonyms: 甲苯磺酸索拉非尼(Standard))

目录号: HY-10201AR 纯度: ≥98%
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Sorafenib (Tosylate) (Standard)是 Sorafenib (Tosylate) 的分析标准品。本产品用于研究及分析应用。Sorafenib Tosylate (Bay 43-9006 Tosylate) 是一种有效的口服活性 Raf 抑制剂，对 Raf-1 和 B-Raf 的 IC50 分别为 6 nM 和 20 nM。Sorafenib Tosylate 是一种多激酶抑制剂，对 VEGFR2，VEGFR3，PDGFRβ，FLT3 和 c-Kit 的 IC50 分别为 90 nM，15 nM，20 nM，57 nM 和 58 nM。Sorafenib Tosylate 诱导细胞自噬 (autophagy) 和凋亡 (apoptosis)，并具有抗肿瘤活性。Sorafenib Tosylate 也是一种 ferroptosis 激动剂。

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Sorafenib (Tosylate) (Standard) Chemical Structure

Sorafenib (Tosylate) (Standard) Chemical Structure

CAS No. : 475207-59-1

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生物活性

Sorafenib (Tosylate) (Standard) is the analytical standard of Sorafenib (Tosylate). This product is intended for research and analytical applications. Sorafenib Tosylate (Bay 43-9006 Tosylate) is a potent and orally active Raf inhibitor with IC50s of 6 nM and 20 nM for Raf-1 and B-Raf, respectively. SorafenibTosylate is a multikinase inhibitor with IC50s of 90 nM, 15 nM, 20 nM, 57 nM and 58 nM for VEGFR2, VEGFR3, PDGFRβ, FLT3 and c-Kit, respectively. Sorafenib Tosylate induces autophagy and apoptosis. Sorafenib Tosylate has anti-tumor activity. Sorafenib Tosylate is a ferroptosis activator.

分子量

637.03

Formula

C28H24ClF3N4O6S
CAS 号
中文名称

甲苯磺酸索拉非尼(Standard)
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

Sorafenib (Tosylate) (Standard) 相关分类

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Keywords:

Sorafenib (Tosylate) (Standard)475207-59-1甲苯磺酸索拉非尼(Standard)RafVEGFRFLT3AutophagyFerroptosisApoptosisRaf kinasesVascular endothelial growth factor receptorCluster of differentiation antigen 135CD135Fms like tyrosine kinase 3Inhibitorinhibitorinhibit

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