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  3. Sp-8-Cl-cAMPS

Sp-8-Cl-cAMPS 是 cAMP (HY-B1511) 的类似物,也是 Sp-8-Cl-cAMP 的衍生物。Sp-8-Cl-cAMPS 抑制人白血病细胞 HL-60 和结肠癌细胞 LS-174T 的生长,IC50 为 8-100 μM。Sp-8-Cl-cAMPS 激活蛋白激酶 cAKIcAKIIKa 分别为 0.25 和 3.2 μM。

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Sp-8-Cl-cAMPS Chemical Structure

Sp-8-Cl-cAMPS Chemical Structure

CAS No. : 142754-28-7

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Sp-8-Cl-cAMPS is an analog of cAMP (HY-B1511) and a derivative of Sp-8-Cl-cAMP. Sp-8-Cl-cAMPS inhibits the growth of human leukemia cell HL-60 and colon cancer cell LS-174T, with IC50 of 8-100 μM. Sp-8-Cl-cAMPS activates the protein kinases cAKI and cAKII, with Ka of 0.25 and 3.2 μM[1].

分子量

379.72

Formula

C10H11ClN5O5PS

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

Sp-8-Cl-cAMPS 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Sp-8-Cl-cAMPS
目录号:
HY-137632
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