2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. SR-8993

SR-8993是一种高选择性、能够穿透血脑屏障的nociceptin受体激动剂，具有减少酒精摄入和缓解戒断焦虑的活性。SR-8993在动物模型中显示出轻度的抗焦虑作用，并能够有效逆转由急性酒精戒断引起的焦虑。SR-8993进一步减少了限制性饮水、对于酒精的操作性反应以及通过长时间间歇性接触酒精诱导的饮酒增加。SR-8993还减轻了与压力和线索相关的酒精寻求复发。

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SR-8993 Chemical Structure

SR-8993 Chemical Structure

CAS No. : 1594121-16-0

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SR-8993 相关抗体

Top Publications Citing Use of Products

查看 Opioid Receptor 亚型特异性产品:

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μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SR-8993 is a highly selective nociceptin receptor agonist that can penetrate the blood-brain barrier and has the activity of reducing alcohol intake and relieving withdrawal anxiety. SR-8993 has shown mild anxiolytic effects in animal models and can effectively reverse anxiety caused by acute alcohol withdrawal. SR-8993 further reduces restricted drinking, operant responses for alcohol, and increased drinking induced by long-term intermittent exposure to alcohol. SR-8993 also reduces stress- and cue-related alcohol-seeking relapse[1].

分子量

412.59

Formula

C25H37FN4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SR-8993 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SR-89931594121-16-0SR8993SR 8993Opioid ReceptorInhibitorinhibitorinhibit

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目录号：
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