1. Neuronal Signaling
  2. Dopamine Transporter Serotonin Transporter
  3. SRI-29574

SRI-29574 是一种多巴胺转运体 (DAT) 的别构调节剂。SRI-29574 部分抑制了 DAT 的摄取 (IC50=2.3 nM) 也部分抑制了羟色胺转运体 (SERT) 和去甲肾上腺素转运体 (NET) 的摄取。SRI-29574 可作为研究 DAT 功能和调节机制的有用探针。

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SRI-29574 Chemical Structure

SRI-29574 Chemical Structure

CAS No. : 1928712-46-2

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  • 生物活性

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生物活性

SRI-29574 is an allosteric modulator of the dopamine transporter (DAT). SRI-29574 partially inhibits the uptake of the DAT (IC50=2.3 nM) and also partially inhibits the uptake of the serotonin transporter (SERT) and norepinephrine transporter (NET). SRI-29574 may serve as a useful probe to study the function and regulatory mechanisms of DAT[1].

分子量

441.53

Formula

C29H23N5

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

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参考文献
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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
SRI-29574
目录号:
HY-126158
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