2. JAK/STAT Signaling Stem Cell/Wnt Apoptosis
  3. STAT Apoptosis
  4. STAT3-IN-10

STAT3-IN-10 是一种 STAT3 抑制剂，IC50 为 5.18 µM。STAT3-IN-10 与 STAT3 SH2 结构域直接结合，抑制肿瘤细胞生长和诱导肿瘤细胞的凋亡 (apoptosis)。

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STAT3-IN-10 Chemical Structure

STAT3-IN-10 Chemical Structure

CAS No. : 2499491-04-0

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STAT3-IN-10 相关抗体

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查看 STAT 亚型特异性产品:

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STAT3 STAT5 STAT6 STAT1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

STAT3-IN-10 is a STAT3 inhibitor with an IC50 value of 5.18 µM. STAT3-IN-10 directly binds to STAT3 SH2 domain, induces cancer cells apoptosis[1].

IC50 & Target

STAT3

5.18 μM (IC50)

体外研究
(In Vitro)

STAT3-IN-10 (A11) (48 h) shows IC50 values of 0.67, 0.77, 1.24 µM against MDA-MB-231, MDA-MB-468, HepG2 cells, respectively[1].
STAT3-IN-10 (A11) directly binds to the STAT3 SH2 domain [1].
STAT3-IN-10 (A11) (0-3 μM, 24 h) inhibits the phosphorylation of STAT3 and its downstream target proteins and has a good selectivity against the tumor suppressor STAT1 [1].
STAT3-IN-10 (A11) (0-4 μM, 24 h) induces apoptosis in cancer cells[1].
STAT3-IN-10 (A11) (0-4 μM, 24 h) dose-dependently causes a significant S phase arrest in MDA-MB-231 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

STAT3-IN-10 相关抗体:

Cell Viability Assay[1]

Cell Line: Breast cancer cell lines: MDA-MB-231 and MDA-MB-468; human liver carcinoma cell line: HepG2.
Concentration:
Incubation Time: 48 h, re-incubated for 4 h (MDA-MB-468, MDA-MB-231) and 1h (HepG2).
Result: Showed IC50 values of 0.67, 0.77, 1.24 µM against MDA-MB-231, MDA-MB-468, HepG2 cells, respectively.

Western Blot Analysis[1]

Cell Line: MDA-MB-231.
Concentration: 0, 0.75, 1.5 and 3.0 μM.
Incubation Time: 24 h.
Result: Decreased the STAT3-Y705 phosphorylation without affecting the total amount of STAT3 protein and decreased the expression of STAT3 target genes, including C-Myc and Cyclin D1 in a dose-dependent manner. Had little impact on the level of STAT1 and its phosphorylation on Tyr701.

Apoptosis Analysis[1]

Cell Line: MDA-MB-231.
Concentration: 0, 1, 2, and 4 μM.
Incubation Time: 24 h.
Result: Induced the apoptosis in MDA-MB-231 cells in a concentration-dependent manner

Cell Cycle Analysis[1]

Cell Line: MDA-MB-231.
Concentration: 0, 1, 2, and 4 μM.
Incubation Time: 24 h.
Result: Could dose-dependently cause a significant S phase arrest in MDA-MB-231 cells
体内研究
(In Vivo)

STAT3-IN-10 (A11) (i.p.; 5, 10 mg/kg; once a day, 21 days) inhibits the growth of human xenograft tumor in vivo[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Five weeks old female BALB/c nude mice (16–18g) bearing inoculation of human breast cancer cells MDA-MB-231[1].
Dosage: 5 and 10 mg/kg
Administration: IP, once a day, 21 days
Result: Inhibited the growth of human xenograft tumor in vivo without apparent body-weight loss for treated mice and inhibited the levels of p-STAT3 in tumor tissues.
分子量

311.29

Formula

C17H13NO5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

STAT3-IN-10 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

STAT3-IN-102499491-04-0STATApoptosisMDA-MB-231HepG2antitumorInhibitorinhibitorinhibit

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