2. JAK/STAT Signaling Stem Cell/Wnt
  3. STAT
  4. STAT3-IN-5

STAT3-IN-5 是一种有效的 STAT3 抑制剂。STAT3-IN-5 抑制 STAT3-Y705 磷酸化，EC50 值为 170 nM。STAT3-IN-5 抑制细胞因子诱导的 JAK 激活。STAT3-IN-5 诱导细胞凋亡 (apoptosis)。STAT3-IN-5 可用于癌症研究。

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STAT3-IN-5 Chemical Structure

STAT3-IN-5 Chemical Structure

CAS No. : 1041438-68-9

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STAT3-IN-5 相关抗体

Top Publications Citing Use of Products

查看 STAT 亚型特异性产品:

查看所有亚型
STAT3 STAT5 STAT6 STAT1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

STAT3-IN-5 is a potent STAT3 inhibitor. STAT3-IN-5 inhibits STAT3-Y705 phosphorylation with an EC50 value of 170 nM. STAT3-IN-5 inhibits cytokine induced JAK activation. STAT3-IN-5 induces apoptosis. STAT3-IN-5 can be used in research of cancer[1].

IC50 & Target[1]

p-STAT3

170 nM (EC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
U-266 EC50
0.17 μM
Compound: 8
Inhibition of STAT3 Y705 phosphorylation in human U266 cells by Western blot analysis
Inhibition of STAT3 Y705 phosphorylation in human U266 cells by Western blot analysis
[PMID: 18578470]
体外研究
(In Vitro)

STAT3-IN-5 (compound 8; 0-2 μM; 1 h) 抑制 U266 细胞中的 STAT3 磷酸化[1]。
STAT3-IN-5 (0-2 μM; 1 h) 抑制 U266 细胞中细胞因子诱导的 JAK1、JAK2 和 Tyk2 磷酸化[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

STAT3-IN-5 相关抗体:

Western Blot Analysis[1]

Cell Line: U266 cells
Concentration: 0-2 μM
Incubation Time: 1 hours
Result: Inhibited cytokine induced phosphorylation of JAK1, JAK2, and Tyk2 (P-JAK1-Y1022/1023, P-JAK2-Y1007/1008, P-Tyk2-Y1054/1055).

Western Blot Analysis[1]

Cell Line: U266 cells
Concentration: 0-2 μM
Incubation Time: 1 hours
Result: Inhibited STAT3 phosphorylation in a dose-dependent manner.
分子量

444.26

Formula

C19H7F7N2O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

STAT3-IN-5 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

STAT3-IN-51041438-68-9STATSTAT3-Y705phosphorylationcytokinecancerU266 cellsInhibitorinhibitorinhibit

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