2. Apoptosis Stem Cell/Wnt JAK/STAT Signaling
  3. Apoptosis STAT
  4. STAT3-IN-9

STAT3-IN-9 是一种有效的 STAT3 抑制剂。STAT3-IN-9 抑制 STAT3 (Tyr705) 的激活，而不影响 STAT1 (Tyr701) 的磷酸化。STAT3-IN-9 诱导细胞凋亡 (apoptosis) 和细胞周期停滞在 G2/M 期。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

STAT3-IN-9 Chemical Structure

STAT3-IN-9 Chemical Structure

CAS No. : 2987726-27-0

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

STAT3-IN-9 相关抗体

Top Publications Citing Use of Products

查看 STAT 亚型特异性产品:

查看所有亚型
STAT3 STAT5 STAT6 STAT1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

STAT3-IN-9 is a potent STAT3 inhibitor. STAT3-IN-9 inhibits the activation of STAT3 (Tyr705) without influencing the phosphorylation of STAT1 (Tyr701). STAT3-IN-9 induces apoptosis and cell cycle arrest at the G2/M phase[1].

IC50 & Target

STAT3

 

体外研究
(In Vitro)

STAT3-IN-9 (compound C6) (48 h) shows potent in vitro anti-tumor activity with IC50s of 0.16, 5.80, 1.63, 5.73, >25, >25 µM for MDA-MB-468, MDA-MB-231, HepG2, A549, U251, HCT116 cells, respectively[1].
STAT3-IN-9 (0, 0.2, 1.0, 5.0 µM; 24 h) inhibits the activation of STAT3 (Tyr705) without influencing the phosphorylation of STAT1 (Tyr701)[1].
STAT3-IN-9 (0, 0.2, 1 µM; 24 h) induces apoptosis through the mitochondrial Caspase dependent apoptotic pathway[1].
STAT3-IN-9 (0, 0.2, 1 µM; 24 h) induces cell cycle arrest at the G2/M phase in a dose-dependent manner[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

STAT3-IN-9 相关抗体:

Cell Proliferation Assay[1]

Cell Line: MDA-MB-468, MDA-MB-231, HepG2, A549, U251, HCT116 cells
Concentration:
Incubation Time: 48 h
Result: Showed potent in vitro anti-tumor activity with IC50s of 0.16, 5.80, 1.63, 5.73, >25, >25 µM for MDA-MB-468, MDA-MB-231, HepG2, A549, U251, HCT116 cells, respectively.

Western Blot Analysis[1]

Cell Line: MDA-MB-468 cells
Concentration: 0, 0.2, 1.0, 5.0 µM
Incubation Time: 24 h
Result: Inhibited the activation of STAT3 (Tyr705) without influencing the phosphorylation of STAT1 (Tyr701).

Apoptosis Analysis[1]

Cell Line: MDA-MB-468 cells
Concentration: 0, 0.2, 1 µM
Incubation Time: 24 h
Result: Induced apoptosis through the mitochondrial Caspase dependent apoptotic pathway.

Cell Cycle Analysis[1]

Cell Line: MDA-MB-468 cells
Concentration: 0, 0.2, 1 µM
Incubation Time: 24 h
Result: Cells were arrest at the G2/M phase in a dose-dependent manner.
分子量

391.42

Formula

C22H21N3O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

STAT3-IN-9 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

STAT3-IN-92987726-27-0ApoptosisSTATMDA-MB-468 cellsapoptosisG2/Mphosphorylationanti-tumorconcentration-dependentInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
STAT3-IN-9
目录号：
HY-146666
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z