2. Metabolic Enzyme/Protease
  3. Steroid Sulfatase
  4. Steroid sulfatase/17β-HSD1-IN-4

Steroid sulfatase/17β-HSD1-IN-4 

目录号: HY-151202
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摩尔计算器

Steroid sulfatase/17β-HSD1-IN-4 (compound 37) 是一种类固醇硫酸酯酶 (STS) 和 17β-羟基类固醇脱氢酶 1 型 (17β HSD1) 双重抑制剂。Steroid sulfatase/17β-HSD1-IN-4 不可逆地抑制 hSTS 的活性，其 IC50 值为 63 nM。Steroid sulfatase/17β-HSD1-IN-4 可用于子宫内膜异位症及其他雌激素依赖性疾病的研究。

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Steroid sulfatase/17β-HSD1-IN-4 Chemical Structure

Steroid sulfatase/17β-HSD1-IN-4 Chemical Structure

CAS No. : 2990549-94-3

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Steroid sulfatase/17β-HSD1-IN-4 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Steroid sulfatase/17β-HSD1-IN-4 (compound 37) is a dual inhibitor of steroid sulfatase (STS) and 17β-hydroxysteroid dehydrogenase type 1 (17β HSD1). Steroid sulfatase/17β-HSD1-IN-4 irreversibly inhibits hSTS activity with anIC50 value of 63 nM. Steroid sulfatase/17β-HSD1-IN-4 can be used in the study of endometriosis and other estrogen-dependent diseases[1].

IC50 & Target

IC50: 63 nM (hSTS)[1].
体外研究
(In Vitro)

Steroid sulfatase/17β-HSD1-IN-4 (compound 37) (0-1100 nM, 24 h) inhibits human steroid sulfatase (hSTS) with an IC50 value of 63 nM and acts on irreversible inhibition of hSTS with an IC50 value of 60 nM in T47D human breast cancer cells[1].
Steroid sulfatase/17β-HSD1-IN-4 (compound 37) (20 μM, 48 h) inhibits HEK-293 cells growth by 15.1% at a concentration of 20 μM with low cytotoxicity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Steroid sulfatase/17β-HSD1-IN-4 相关抗体:
分子量

403.48

Formula

C18H17N3O4S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Steroid sulfatase/17β-HSD1-IN-4 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Steroid sulfatase/17β-HSD1-IN-42990549-94-3Steroid Sulfatasesteroid sulfataseSTS17β HSD1endometriosisestrogen-dependent diseasesInhibitorinhibitorinhibit

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