2. Metabolic Enzyme/Protease
  3. Steroid Sulfatase
  4. Steroid sulfatase/17β-HSD1-IN-1

Steroid sulfatase/17β-HSD1-IN-1 

目录号: HY-151199
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摩尔计算器

Steroid sulfatase/17β-HSD1-IN-1 是一种有效的类固醇硫酸酯酶 (steroid sulfatase) 和 17β-羟甾类固醇脱氢酶 1 型 (17β-HSD1) 抑制剂，对胞内人类固醇硫酸酯酶的 IC50 为 28 nM。Steroid sulfatase/17β-HSD1-IN-1 可用于雌激素依赖性疾病的研究。

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Steroid sulfatase/17β-HSD1-IN-1 Chemical Structure

Steroid sulfatase/17β-HSD1-IN-1 Chemical Structure

CAS No. : 2990549-70-5

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Steroid sulfatase/17β-HSD1-IN-1 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Steroid sulfatase/17β-HSD1-IN-1 is a potent steroid sulfatase and 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) inhibitor with an IC50 value of 28 nM for cellular human steroid sulfatase. Steroid sulfatase/17β-HSD1-IN-1 can be used to research estrogen-dependent diseases[1].

IC50 & Target

IC50: 28 nM (cellular human steroid sulfatase)[1]
体外研究
(In Vitro)

Steroid sulfatase/17β-HSD1-IN-1 (compound 13) (20 μM; 48 h) has a low cytotoxicity in HEK-293 cells[1].
Steroid sulfatase/17β-HSD1-IN-1 (50-750 nM; 0-25 min) can inhibit T47D cells growth and 17β-HSD1 in a time-dependent manner[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Steroid sulfatase/17β-HSD1-IN-1 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: HEK-293 cells
Concentration: 20 μM
Incubation Time: 48 h
Result: Exhibited a low cytotoxicity with the cell growth inhibition of 12.8%.

Cell Proliferation Assay[1]

Cell Line: T47D
Concentration: 50, 100, 250, 500 and 750 nM
Incubation Time: 0-25 min
Result: Inhibited cell growth and 17β-HSD1 in a time-dependent manner.
体内研究
(In Vivo)

Steroid sulfatase/17β-HSD1-IN-1 shows good metabolic stability in human hepatic S9 fraction (t1/2=47 min) and low intrinsic clearance Clint (15 μL/min/mg protein)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

386.42

Formula

C19H18N2O5S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Steroid sulfatase/17β-HSD1-IN-1 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Steroid sulfatase/17β-HSD1-IN-12990549-70-5Steroid Sulfatasesteroid sulfatase17β-HSD1estrogenHEK-293 cellsT47DInhibitorinhibitorinhibit

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