2. Metabolic Enzyme/Protease
  3. Steroid Sulfatase
  4. Steroid sulfatase-IN-2

Steroid sulfatase-IN-2 是一种有活性的类固醇硫酸酯酶 (STS) 抑制剂，IC50 值为 109.5 nM。Steroid sulfatase-IN-2 可用于激素依赖性癌症的研究，如雌激素依赖性乳腺癌和子宫内膜癌。

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Steroid sulfatase-IN-2 Chemical Structure

Steroid sulfatase-IN-2 Chemical Structure

CAS No. : 2413880-39-2

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Steroid sulfatase-IN-2 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Steroid sulfatase -IN-2 is an active steroid sulfatase (STS) inhibitor with an IC50 value of 109.5 nM. Steroid sulfatase-IN-2 can be used for the research of hormone-dependent cancers, such as estrogen-dependent breast and endometrial cancer[1].

IC50 & Target

IC50：109.5 nM (STS)[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
JEG-3 IC50
109.5 nM
Compound: 1h
Inhibition of steroid sulfatase in human JEG3 cell lysates using [3H] E1S as substrate after 1 hr by scintillation spectrometry analysis
Inhibition of steroid sulfatase in human JEG3 cell lysates using [3H] E1S as substrate after 1 hr by scintillation spectrometry analysis
[PMID: 32173116]
JEG-3 IC50
13.6 nM
Compound: 1h
Inhibition of steroid sulfatase in human JEG3 cells using [3H] E1S as substrate incubated for 20 hrs by scintillation spectrometry analysis
Inhibition of steroid sulfatase in human JEG3 cells using [3H] E1S as substrate incubated for 20 hrs by scintillation spectrometry analysis
[PMID: 32173116]
T47D IC50
5.78 μM
Compound: 1h
Antiproliferative activity against human T47D cells assessed as reduction in cell proliferation measured after 5 days in presence of estradiol sulfate by crystal violet staining based assay
Antiproliferative activity against human T47D cells assessed as reduction in cell proliferation measured after 5 days in presence of estradiol sulfate by crystal violet staining based assay
[PMID: 32173116]
体外研究
(In Vitro)

Steroid sulfatase-IN-2 (compound 1h, 0.001-10 μM, 1 h) inhibits STS in the lysate of JEG-3 cells, with an IC50 value of 109.5 nM[1].
Steroid sulfatase-IN-2 (1-1 μM, 20 h) inhibits STS in a whole-cell assay against JEG-3 cells, with an IC50 value of 13.6 nM[1].
Steroid sulfatase-IN-2 (0.01-100 μM, 5 days) shows dose-dependent antiproliferative activity against T-47D estrogen-dependent breast cancer cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Steroid sulfatase-IN-2 相关抗体:

Cell Viability Assay[1]

Cell Line: T-47D cells
Concentration: 0.01-100 μM
Incubation Time: 5 days
Result: Inhibited cell proliferation with an IC50 value of 5.78 μM.
分子量

350.43

Formula

C17H22N2O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Steroid sulfatase-IN-2 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Steroid sulfatase-IN-22413880-39-2Steroid SulfataseSTS inhibitionJEG-3T-47DproliferationhormonecancerInhibitorinhibitorinhibit

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