2. Metabolic Enzyme/Protease
  3. Steroid Sulfatase
  4. Steroid sulfatase-IN-3

Steroid sulfatase-IN-3 (compound 1q) 是一种有效的 STS (甾体磺胺脂酶)抑制剂，其 IC50 为 25.8 nM。Steroid sulfatase-IN-3 (compound 1q) 对 T-47D 雌激素依赖性乳腺癌细胞具有抗增殖活性，其 IC50 为 1.04 μM。

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Steroid sulfatase-IN-3 Chemical Structure

Steroid sulfatase-IN-3 Chemical Structure

CAS No. : 2413880-53-0

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Steroid sulfatase-IN-3 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Steroid sulfatase-IN-3 (compound 1q) is a potent STS (Steroid sulfatase) inhibitor, with an IC50 of 25.8 nM. Steroid sulfatase-IN-3 shows antiproliferative activity against T-47D estrogen-dependent breast cancer cells, with an IC50 of 1.04 µM[1].

IC50 & Target

IC50: 25.8 nM (STS, in JEG-3 cell lysate), 150.0 nM (STS, in JEG-3 cells)[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
JEG-3 IC50
150 nM
Compound: 1q
Inhibition of steroid sulfatase in human JEG3 cells using [3H] E1S as substrate incubated for 20 hrs by scintillation spectrometry analysis
Inhibition of steroid sulfatase in human JEG3 cells using [3H] E1S as substrate incubated for 20 hrs by scintillation spectrometry analysis
[PMID: 32173116]
JEG-3 IC50
25.8 nM
Compound: 1q
Inhibition of steroid sulfatase in human JEG3 cell lysates using [3H] E1S as substrate after 1 hr by scintillation spectrometry analysis
Inhibition of steroid sulfatase in human JEG3 cell lysates using [3H] E1S as substrate after 1 hr by scintillation spectrometry analysis
[PMID: 32173116]
T47D IC50
1.04 μM
Compound: 1q
Antiproliferative activity against human T47D cells assessed as reduction in cell proliferation measured after 5 days in presence of estradiol sulfate by crystal violet staining based assay
Antiproliferative activity against human T47D cells assessed as reduction in cell proliferation measured after 5 days in presence of estradiol sulfate by crystal violet staining based assay
[PMID: 32173116]
分子量

384.88

Formula

C17H21ClN2O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Steroid sulfatase-IN-3 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Steroid sulfatase-IN-32413880-53-0Steroid SulfataseT-47D cellsAdamantylAntiproliferative activityBreast cancerJEG-3Steroid sulfataseT-47Dplacental choriocarcinomabreast cancerInhibitorinhibitorinhibit

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