2. Metabolic Enzyme/Protease NF-κB Immunology/Inflammation
  3. Endogenous Metabolite Reactive Oxygen Species
  4. Succinyl phosphonate

Succinyl phosphonate  (Synonyms: 琥珀酰膦酸盐)

目录号: HY-12688
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摩尔计算器

Succinyl phosphonate 是 α-酮戊二酸脱氢酶 (KGDHC ) 抑制剂，可有效抑制肌肉，细菌，脑和人成纤维细胞中的 KGDHC。Succinyl phosphonate trisodium salt 抑制 2-氧代戊二酸脱氢酶 (OGDH)，以细胞特异性代谢依赖性方式损害癌细胞的活力。Succinyl phosphonate trisodium salt 抑制谷氨酸诱导的谷氨酸刺激的海马神经元中的 ROS 产生。

在相同的摩尔浓度下，化合物盐形式与游离形式有相同的生物活性，但盐形式 Succinyl phosphonate trisodium salt 通常具有更好的水溶性和稳定性。

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Succinyl phosphonate Chemical Structure

Succinyl phosphonate Chemical Structure

CAS No. : 26647-82-5

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Succinyl phosphonate 的其他形式现货产品:

Other Forms of Succinyl phosphonate:

Succinyl phosphonate 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Succinyl phosphonate is an α-ketoglutarate dehydrogenase (KGDHC) inhibitor, effective inhibits (KGDHC) in muscle, bacterial, brain, and cultured human fibroblasts[1][4]. Succinyl phosphonate trisodium salt is an 2-oxoglutarate dehydrogenase (OGDH) inhibitor, impairs viability of cancer cells in a cell-specific metabolism-dependent manner[2]. Succinyl phosphonate trisodium salt inhibits the glutamate-induced ROS production in glutamate-stimulated hippocampal neurons in situ[3].

IC50 & Target

α-ketoglutarate dehydrogenase; 2-oxoglutarate dehydrogenase[1][4]; ROS production[3]
分子量

182.07

Formula

C4H7O6P
CAS 号
性状

油状物

颜色

Colorless to light yellow

中文名称

琥珀酰膦酸盐
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献
Cell Assay
[3]

MTT assay is employed to test cellular viability. Serial dilutions of succinyl phosphonate (0.01-20 mM) are added to cells in fresh culture media. During the medium exchange before the succinyl phosphonate addition, glioblastoma cells are brought to DMEM with 1 g/L glucose, 1 mM pyruvate and 2 mM glutamax. The influence of succinyl phosphonate in minimal medium is studied in the earlier employed buffered salt solution[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Succinyl phosphonate 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Succinyl phosphonate26647-82-5琥珀酰膦酸盐Endogenous MetaboliteReactive Oxygen SpeciesInhibitorinhibitorinhibit

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