2. Metabolic Enzyme/Protease
  3. Enteropeptidase
  4. Sucunamostat hydrate

Sucunamostat hydrate  (Synonyms: SCO-792)

目录号: HY-130126
产品使用指南

摩尔计算器

Sucunamostat (SCO-792) hydrate 是一种口服有效和可逆的肠肽酶 (enteropeptidase) 抑制剂。Sucunamostat hydrate 能在体外与肠肽酶缓慢解离并在体内抑制蛋白质消化。

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Sucunamostat hydrate Chemical Structure

Sucunamostat hydrate Chemical Structure

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Sucunamostat hydrate 的其他形式现货产品:

Customer Review

Other Forms of Sucunamostat hydrate:

Sucunamostat hydrate 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Sucunamostat hydrate (SCO-792) is an orally active and reversible enteropeptidase inhibitor with IC50s of 4.6 nM and 5.4 nM for rat enteropeptidase and human enteropeptidase, respectively. Sucunamostat hydrate can slowly dissociate from enteropeptidase in vitro and inhibit protein digestion in vivo[1].

IC50 & Target

IC50: 4.6 nM (rat enteropeptidase), 5.4 nM (human enteropeptidase)[1]
体内研究
(In Vivo)

Sucunamostat hydrate (10 和 30 mg/kg；口服，单次剂量) 有效且剂量依赖性地抑制大鼠口服蛋白质剂量诱导的血浆支链氨基酸 (BCAA) 升高[1]。< br/>
Sucunamostat hydrate 在雄性 Sprague-Dawley 大鼠体内的药代动力学参数[1]

PO (10 mg/kg) IV (2 mg/kg)
Cmax (ng/mL) 6.60 ± 1.36 564 ± 58
Tmax (h) 1.7 ± 0.6
AUC0-24 (ng/mL·h) 54.1 ± 7.5 303 ± 23
AUCinf (ng/mL·h) 49.8 ± 5.4 304 ± 30
VdSS (mL/kg) 1290 ± 299
CLp (mL/min/kg) 663 ± 66
bioavailability (%) 0.4

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Formula

C22H22N4O8.xH2O
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Sucunamostat hydrate 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SucunamostatSCO-792SCO792SCO 792EnteropeptidaseEnterokinaseTransmembrane serine protease 15TMPRSS15Digestionprotein digestionorally activeInhibitorinhibitorinhibit

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