2. Immunology/Inflammation
  3. Nuclear Factor of activated T Cells (NFAT)
  4. Sulfo galactosylceramide

Sulfo galactosylceramide  (Synonyms: (3'-sulfo)Galβ-Cer(d18:1/24:1); N-Nervonoyl Sulfatide; C24:1 Sulfatide)

目录号: HY-125726
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Sulfo galactosylceramide (N-Nervonoyl Sulfatide; C24:1 Sulfatide) 是糖脂类中的一种，是成熟髓鞘中的主要硫脂种类。Sulfo galactosylceramide 与 C 型凝集素 (lectin) 和免疫球蛋白样受体相互作用，对 LMIR5 的亲和力最高。Sulfo galactosylceramide 可诱导嗜碱性粒细胞而不是肥大细胞产生 MCP-1，并通过 LMIR5 增加 NFAT 的活化。Sulfo galactosylceramide 可以减轻慢性复发缓解型实验性自身免疫性脑脊髓炎 (EAE) 小鼠模型的症状并提高存活率，减少 EAE 小鼠腰椎脊髓中的炎症病变和浸润性单核细胞的数量。

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Sulfo galactosylceramide Chemical Structure

Sulfo galactosylceramide Chemical Structure

CAS No. : 151057-28-2

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Sulfo galactosylceramide 相关抗体

Top Publications Citing Use of Products

  • 生物活性

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生物活性

Sulfo galactosylceramide (N-Nervonoyl Sulfatide; C24:1 Sulfatide) is a glycolipid and the major sulfolipid species in mature myelin. Sulfo galactosylceramide interacts with C-type lectins and immunoglobulin-like receptors, with the highest affinity for LMIR5. Sulfo galactosylceramide induces MCP-1 production by basophils but not mast cells, and increases NFAT activation via LMIR5. Sulfo galactosylceramide alleviates symptoms and improves survival in a mouse model of chronic relapsing-remitting experimental autoimmune encephalomyelitis (EAE), and reduces inflammatory lesions and the number of infiltrating mononuclear cells in the lumbar spinal cord of EAE mice.

分子量

890.30

Formula

C48H91NO11S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Sulfo galactosylceramide 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sulfo galactosylceramide151057-28-2(3'-sulfo)Galβ-Cer(d18:1/24:1) N-Nervonoyl Sulfatide C24:1 SulfatideNuclear Factor of activated T Cells (NFAT)Inhibitorinhibitorinhibit

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