2. Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease Cell Cycle/DNA Damage Autophagy Apoptosis
  3. Estrogen Receptor/ERR HSP Autophagy Apoptosis
  4. Tamoxifen Citrate (Standard)

Tamoxifen Citrate (Standard)  (Synonyms: 枸橼酸他莫昔芬 (Standard))

目录号: HY-13757R 纯度: ≥98%
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Tamoxifen (Citrate) (Standard) 是 Tamoxifen (Citrate) 的分析标准品。本产品用于研究及分析应用。Tamoxifen Citrate (ICI 46474) 是一种口服有效的，选择性雌激素受体调节剂 (SERM)，可阻断乳腺细胞中的雌激素作用，并可激活其他细胞，如骨骼，肝脏和子宫细胞中的雌激素活性。Tamoxifen Citrate 是一种有效的 Hsp90 激活剂，可增强 Hsp90 分子伴侣 ATPase 的活性。Tamoxifen Citrate 还可以有效抑制传染性 EBOV Zaire 和 Marburg (MARV)，IC50 分别为 0.1 μM 和 1.8 μM。Tamoxifen Citrate 可以激活自噬 (autophagy)，诱导凋亡 (apoptosis)。Tamoxifen Citrate 还可以诱导 CreER(T2) 转基因小鼠的基因敲除。

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Tamoxifen Citrate (Standard) Chemical Structure

Tamoxifen Citrate (Standard) Chemical Structure

CAS No. : 54965-24-1

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生物活性

Tamoxifen (Citrate) (Standard) is the analytical standard of Tamoxifen (Citrate). This product is intended for research and analytical applications. Tamoxifen Citrate (ICI 46474) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells.Tamoxifen Citrate is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen Citrate also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 μM and 1.8 μM, respectively. Tamoxifen Citrate activates autophagy and induces apoptosis.Tamoxifen Citrate also can induce gene knockout of CreER(T2) transgenic mouse.

分子量

563.64

Formula

C₃₂H₃₇NO₈
CAS 号
中文名称

枸橼酸他莫昔芬 (Standard)； 他莫昔芬柠檬酸盐 (Standard)
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

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Keywords:

Tamoxifen Citrate (Standard)54965-24-1枸橼酸他莫昔芬 (Standard) 他莫昔芬柠檬酸盐 (Standard)Estrogen Receptor/ERRHSPAutophagyApoptosisHeat shock proteinsestrogenmodulatorSERMbreastboneliveruterineHsp90chaperoneATPaseInhibitorinhibitorinhibit

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