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  4. Taurolithocholic acid

Taurolithocholic acid 是一种胆汁酸，具有在肝内胆管癌细胞系RMCCA-1中浓度依赖性地增加细胞活力、诱导细胞周期S期以及促进DNA合成的活性，还可增加RMCCA-1细胞中EGFR、ERK 1/2的磷酸化以及细胞周期蛋白D1的表达，并且其诱导的RMCCA-1细胞生长可被特定的拮抗剂和抑制剂所抑制。

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Taurolithocholic acid Chemical Structure

Taurolithocholic acid Chemical Structure

CAS No. : 516-90-5

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Taurolithocholic acid 的其他形式现货产品:

Taurolithocholic acid 相关抗体

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生物活性

Taurolithocholic acid is a bile acid that has the activity of increasing cell viability, inducing the S phase of the cell cycle, and promoting DNA synthesis in a concentration-dependent manner in the intrahepatic cholangiocarcinoma cell line RMCCA-1. It can also increase the phosphorylation of EGFR and ERK 1/2 and the expression of cyclin D1 in RMCCA-1 cells, and its induced RMCCA-1 cell growth can be inhibited by specific antagonists and inhibitors.

IC50 & Target

Human Endogenous Metabolite

 

分子量

483.70

Formula

C26H45NO5S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Taurolithocholic acid 相关分类

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Keywords:

Taurolithocholic acid516-90-5OthersInhibitorinhibitorinhibit

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