2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR
  4. TC299423

TC299423 是具有口服活性，通过血脑屏障，选择性且强效的 α6β2∗ 和 α4β2∗ 尼古丁乙酰胆碱受体 (nAChRs) 的激动剂，具有抗焦虑和镇痛特性。TC299423 主要通过与焦虑相关的尼古丁作用于 α6β2∗ nAChRs。TC299423 在对 α6L90’S 超敏感的状态下引发小鼠与奖励相关的行为，主要是通过 α6β2∗ nAChRs 介导。TC299423 促进多巴胺释放，且不会抑制大鼠的尼古丁自我给药。TC299423 有望用于成瘾和帕金森病的研究。

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TC299423 Chemical Structure

TC299423 Chemical Structure

CAS No. : 1975146-56-5

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TC299423 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TC299423 is an orally active, brain-penetrant, selective and potent agonist for α6β2∗ and α4β2∗ nicotinic acetylcholine receptors (nAChRs) with anxiolytic and antinociceptive properties. TC299423 acts primarily through α6β2∗ nAChRs that are implicated in the anxiolytic effects of nicotine. TC299423 elicits reward-related behavior mediated through α6β2∗ nAChRs in hypersensitive α6L90’S mice. TC299423 elicits dopamine release and dose not suppress nicotine self-administration in rats. TC299423 is proming for rasearch of addiction and Parkinson’s disease[1][2].

分子量

189.26

Formula

C11H15N3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TC299423 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TC2994231975146-56-5TC 299423TC-299423nAChRNicotinic acetylcholine receptorsorally activebrain-penetrantα6β2? α4β2? nAChRsanxiolyticantinociceptivereward-related behavioraddictionParkinson’s diseaseInhibitorinhibitorinhibit

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