2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR
  4. Tebanicline

Tebanicline  (Synonyms: 替巴克兰; Ebanicline; ABT-594)

目录号: HY-14316
产品使用指南

摩尔计算器

Tebanicline，依巴替丁的类似物，是一种神经元型烟碱型乙酰胆碱受体激动剂。Tebanicline 表现出强效抗伤害作用并对中枢神经系统中 α4β2 神经元型烟碱乙酰胆碱受体亚单位具有高亲和力。

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Tebanicline Chemical Structure

Tebanicline Chemical Structure

CAS No. : 198283-73-7

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Tebanicline 的其他形式现货产品:

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Tebanicline 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tebanicline, an analogue of epibatidine, is a neuronal nicotinic acetylcholine receptor agonist. Tebanicline exhibits potent antinociceptive effects and has a high affinity for the α4β2 neuronal nicotinic acetylcholine receptor subunit in the central nervous system.

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
IMR-32 EC50
0.02 μM
Compound: tebeniciline
Agonist activity at human recombinant alpha4beta2 nAChR expressed in human IMR32 cells assessed as calcium dynamics by FLIPR assay
Agonist activity at human recombinant alpha4beta2 nAChR expressed in human IMR32 cells assessed as calcium dynamics by FLIPR assay
[PMID: 19232492]
IMR-32 EC50
0.19 μM
Compound: tebeniciline
Agonist activity at human recombinant alpha3beta4 nAChR expressed in human IMR32 cells assessed as calcium dynamics by FLIPR assay
Agonist activity at human recombinant alpha3beta4 nAChR expressed in human IMR32 cells assessed as calcium dynamics by FLIPR assay
[PMID: 19232492]
分子量

198.65

Formula

C9H11ClN2O
CAS 号
中文名称

替巴克兰
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Tebanicline 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tebanicline198283-73-7Ebanicline ABT-594替巴克兰ABT594ABT 594ABT-594nAChRNicotinic acetylcholine receptorsPaw licking miceAntinociceptiveAnalgesic effectInhibitorinhibitorinhibit

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