2. Apoptosis
  3. Apoptosis
  4. Telomerase-IN-4

Telomerase-IN-4 是一种有效的端粒酶 (telomerase) 抑制剂。Telomerase-IN-4 具有抗增殖活性，诱导细胞凋亡 (apoptosis)。

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Telomerase-IN-4 Chemical Structure

Telomerase-IN-4 Chemical Structure

CAS No. : 2892295-10-0

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Telomerase-IN-4 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Telomerase-IN-4 is a potent telomerase inhibitor. Telomerase-IN-4 has antiproliferative activity and induces apoptosis[1].

体外研究
(In Vitro)

Telomerase-IN-4 (compound 8e; 0.1-100 μg/mL; 72 h) 对两种癌细胞系都有抗肿瘤作用，对 MCF-7 和 A549 细胞的 IC50 值分别为 9.47 和 17.09 μg/mL[1]。
Telomerase-IN-4 (9.467 μg/mL; 48 h) 将细胞周期阻滞在 S 期，诱导 MCF-7 细胞凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Telomerase-IN-4 相关抗体:

Cell Viability Assay[1]

Cell Line: MCF-7 and A549 cells
Concentration: 0.1, 1, 10, and 100 μg/mL
Incubation Time: 72 h
Result: Inhibited cell growth in a dose-dependent manner.

Apoptosis Analysis[1]

Cell Line: MCF-7 cells
Concentration: 9.467 μg/mL
Incubation Time: 48 h
Result: Had an apoptosis percentage of 42.51%.

Cell Cycle Analysis[1]

Cell Line: MCF-7 cells
Concentration: 9.467 μg/mL
Incubation Time: 48 h
Result: Arrested cell cycle at the S phase of cell growth by more than 1.46 folds compared to that of the control.

Western Blot Analysis[1]

Cell Line: MCF-7 cells
Concentration: 9.467 μg/mL
Incubation Time: 48 h
Result: Decreased in ALT and AST levels by 36.12 and 29.77%, respectively.
体内研究
(In Vivo)

Telomerase-IN-4 (5 mg/kg; i.p.; 每周三次，共两周; 瑞士白化雌性小鼠) 具有抗癌活性，抑制肿瘤生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Swiss albino female mice (25-30 g)[1]
Dosage: 5 mg/kg
Administration: Intraperitoneal injectionthree; times per week for two weeks
Result: Reduced both the weight and volume of the tumor by 74.34 and 62.12%, respectively.
分子量

406.52

Formula

C21H18N4OS2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Telomerase-IN-4 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Telomerase-IN-42892295-10-0ApoptosisantiproliferativetumorMCF-7A549S phaseInhibitorinhibitorinhibit

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产品名称：
Telomerase-IN-4
目录号：
HY-152076
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