2. Cell Cycle/DNA Damage Apoptosis
  3. G-quadruplex DNA/RNA Synthesis Apoptosis
  4. Telomeric G4s ligand 1

Telomeric G4s ligand 1 是一种端粒 G-四链体配体，可稳定端粒 G4 并诱导 R 环形成，从而导致 DNA 损伤反应。Telomeric G4s ligand 1 诱导肿瘤细胞凋亡并引发免疫原性细胞死亡 (ICD)。

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Telomeric G4s ligand 1 Chemical Structure

Telomeric G4s ligand 1 Chemical Structure

CAS No. : 3047091-81-3

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Telomeric G4s ligand 1 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Telomeric G4s ligand 1 is a telomeric G-quadruplex ligand that stabilizes telomeric G4 and induces R-loop formation, leading to DNA damage responses. Telomeric G4s ligand 1 induces apoptosis and evokes immunogenic cell death (ICD) in tumor cells[1].

体外研究
(In Vitro)

Telomeric G4s ligand 1（化合物 R1；1-4 μM；24 小时）可稳定 G4 并在 MDA-MB-231 细胞的端粒区域诱导 R 环结构，从而引发 DNA 损伤反应、G2/M 期细胞周期停滞、细胞凋亡和抗增殖[1]。
Telomeric G4s ligand 1 可引发肿瘤细胞的免疫原性细胞死亡 (ICD)，从而促进骨髓衍生树突状细胞 (BMDC) 的成熟[1]。 MDA-MB-231 cells 1 μM, 2 μM, 4 μM 24 h Increased the levels of DNA damage-related proteins, such as γH2AX and replication protein A subunit.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Telomeric G4s ligand 1 相关抗体:

Cell Cycle Analysis[1]

Cell Line: MDA-MB-231 cells
Concentration: 1 μM, 2 μM, 4 μM
Incubation Time: 24 h
Result: Induced cell cycle arrest in G2/M phase and apoptosis.

Western Blot Analysis[1]

Cell Line: MDA-MB-231 cells
Concentration: 1 μM, 2 μM, 4 μM
Incubation Time: 24 h
Result: Increased the levels of DNA damage-related proteins, such as γH2AX and replication protein A subunit.
体内研究
(In Vivo)

Telomeric G4s ligand 1（化合物 R1；10 mg/kg；腹腔注射；每隔一天，持续 14 天）通过免疫调节作用显著降低肿瘤负担，包括乳腺癌小鼠模型中肿瘤中 CD4+ 和 CD8+ T 细胞的增加以及血清中细胞因子水平的增加[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 4-week-old female BALB/c mice injected 4T1 cells[1]
Dosage: 10 mg/kg
Administration: ip; every other day for 14 days
Result: Exhibited the ability to lengthen the survival time of tumor-bearing mice, and resulted in DNA damage and apoptosis in vivo.
分子量

550.66

Formula

C31H37F3N6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Telomeric G4s ligand 1 相关分类

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Keywords:

Telomeric G4s ligand 13047091-81-3G-quadruplexDNA/RNA SynthesisApoptosistelomeric G-quadruplex ligandDNA damageR-loop formationapoptosiscell cycle arrest in G2/M phaseInhibitorinhibitorinhibit

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